Testing the neutral mutation hypothesis by distribution of single locus heterozygosity

Masatoshi Nei, Paul A. Fuerst, Ranajit Chakraborty

Research output: Contribution to journalArticle

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Abstract

ONE of the most controversial issues in population genetics at present is whether the widespread protein variation in natural populations is maintained by some form of balancing selection1-3 or merely represents the drifting polymorphis of neutral or nearly neutral mutations4-6. By the neutral mutation hypothesis the level of genetic variability in an equilibrium population is determined by mutation rate, v, and effective population size, Ne. If we use the infinite allele model, in which new mutations are assumed to be always different from the pre-existing alleles in the population, the average heterozygosity per locus is given by where M =4Nev (ref. 7).

Original languageEnglish
Pages (from-to)491-493
Number of pages3
JournalNature
Volume262
Issue number5568
DOIs
StatePublished - 1 Dec 1976

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Mutation
Alleles
Population
Population Genetics
Mutation Rate
Population Density
Proteins

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Nei, Masatoshi ; Fuerst, Paul A. ; Chakraborty, Ranajit. / Testing the neutral mutation hypothesis by distribution of single locus heterozygosity. In: Nature. 1976 ; Vol. 262, No. 5568. pp. 491-493.
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Testing the neutral mutation hypothesis by distribution of single locus heterozygosity. / Nei, Masatoshi; Fuerst, Paul A.; Chakraborty, Ranajit.

In: Nature, Vol. 262, No. 5568, 01.12.1976, p. 491-493.

Research output: Contribution to journalArticle

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