Tension generation by isolated myofibrils

Julian Borejdo, A. Schweitzer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The technique for mechanical dissection of microscopic myofibrilar bundles containing few myofibrils is described. A sensitive electrooptical tension transducer capable of resolving the tension generated by such myofibrilar bundles to within a fraction of a percent is used to study the response of the preparations to low ATP concentrations. The rate of tension development decreased with a decrease in ATP concentration. Below 10-6 M ATP the myofibrils did not demonstrate any mechanical activity at all. These findings are discussed in terms of the kinetics of the crossbridge cycle.

Original languageEnglish
Pages (from-to)189-204
Number of pages16
JournalJournal of Mechanochemistry and Cell Motility
Issue number3
StatePublished - 1 Dec 1977


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