Telomere Shortening and Alzheimer's Disease

Zhiyou Cai, Liang Jun Yan, Anna Ratka

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Telomeres, at the ends of chromosomes and strands of genetic material, become shorter as cells divide in the process of aging. Telomere length has been considered as a biological marker of age. Telomere length shortening has also been evidenced as the causable role in age-related neurodegenerative diseases, including Alzheimer's disease (AD). It has been demonstrated that telomere shortening has been associated with cognitive impairment, amyloid pathology and hyper-phosphorylation of tau in AD and plays an important role in the pathogenesis of AD via the mechanism of oxidative stress and inflammation. However, it seems that there is no relationship between telomere shortening and AD. Therefore, it is essential for further clarification of telomere-related pathogenesis in AD.

Original languageEnglish
Pages (from-to)25-48
Number of pages24
JournalNeuroMolecular Medicine
Volume15
Issue number1
DOIs
StatePublished - 1 Mar 2013

Keywords

  • Alzheimer's disease
  • Telomere
  • Telomere shortening

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