Task-specific tolerance to d-amphetamine

Michael Oglesby, D. G. Spencer, D. M. Wood, H. Lal

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rats were trained concurrently on sweetened-milk drinking and bar-press-responding behavior, which alternated on a daily basis. Dose-response functions for d-amphetamine were determined before and after conditions of chronic treatment. When given before chronic treatment, d-amphetamine decreased both milk consumption and reinforcement received for lever-pressing in a dose-dependent manner. Subsequently, three conditions of chronic injection were established in which one group received saline, prior to both tasks, another group received d-amphetamine prior to drinking milk and saline prior to lever-pressing and the third group received d-amphetamine prior to lever-pressing and saline before drinking milk. The rats became tolerant to d-amphetamine in the task in which the drug had been administered chronically; however, the same rats showed no tolerance in the other task in which saline had been administered chronically. Tolerance to d-amphetamine was thus shown to be behaviorally specific.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalNeuropharmacology
Volume23
Issue number5
DOIs
StatePublished - 1 Jan 1984

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Dextroamphetamine
Milk
Drinking
Injections
Therapeutics
Pharmaceutical Preparations

Keywords

  • behavioral tolerance
  • d-amphetamine
  • operant behavior
  • tolerance

Cite this

Oglesby, Michael ; Spencer, D. G. ; Wood, D. M. ; Lal, H. / Task-specific tolerance to d-amphetamine. In: Neuropharmacology. 1984 ; Vol. 23, No. 5. pp. 563-568.
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Oglesby, M, Spencer, DG, Wood, DM & Lal, H 1984, 'Task-specific tolerance to d-amphetamine', Neuropharmacology, vol. 23, no. 5, pp. 563-568. https://doi.org/10.1016/0028-3908(84)90030-3

Task-specific tolerance to d-amphetamine. / Oglesby, Michael; Spencer, D. G.; Wood, D. M.; Lal, H.

In: Neuropharmacology, Vol. 23, No. 5, 01.01.1984, p. 563-568.

Research output: Contribution to journalArticle

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