Abstract
Rats were trained concurrently on sweetened-milk drinking and bar-press-responding behavior, which alternated on a daily basis. Dose-response functions for d-amphetamine were determined before and after conditions of chronic treatment. When given before chronic treatment, d-amphetamine decreased both milk consumption and reinforcement received for lever-pressing in a dose-dependent manner. Subsequently, three conditions of chronic injection were established in which one group received saline, prior to both tasks, another group received d-amphetamine prior to drinking milk and saline prior to lever-pressing and the third group received d-amphetamine prior to lever-pressing and saline before drinking milk. The rats became tolerant to d-amphetamine in the task in which the drug had been administered chronically; however, the same rats showed no tolerance in the other task in which saline had been administered chronically. Tolerance to d-amphetamine was thus shown to be behaviorally specific.
| Original language | English |
|---|---|
| Pages (from-to) | 563-568 |
| Number of pages | 6 |
| Journal | Neuropharmacology |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 Jan 1984 |
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Keywords
- behavioral tolerance
- d-amphetamine
- operant behavior
- tolerance
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}
Task-specific tolerance to d-amphetamine. / Oglesby, Michael; Spencer, D. G.; Wood, D. M.; Lal, H.
In: Neuropharmacology, Vol. 23, No. 5, 01.01.1984, p. 563-568.Research output: Contribution to journal › Article
TY - JOUR
T1 - Task-specific tolerance to d-amphetamine
AU - Oglesby, Michael
AU - Spencer, D. G.
AU - Wood, D. M.
AU - Lal, H.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Rats were trained concurrently on sweetened-milk drinking and bar-press-responding behavior, which alternated on a daily basis. Dose-response functions for d-amphetamine were determined before and after conditions of chronic treatment. When given before chronic treatment, d-amphetamine decreased both milk consumption and reinforcement received for lever-pressing in a dose-dependent manner. Subsequently, three conditions of chronic injection were established in which one group received saline, prior to both tasks, another group received d-amphetamine prior to drinking milk and saline prior to lever-pressing and the third group received d-amphetamine prior to lever-pressing and saline before drinking milk. The rats became tolerant to d-amphetamine in the task in which the drug had been administered chronically; however, the same rats showed no tolerance in the other task in which saline had been administered chronically. Tolerance to d-amphetamine was thus shown to be behaviorally specific.
AB - Rats were trained concurrently on sweetened-milk drinking and bar-press-responding behavior, which alternated on a daily basis. Dose-response functions for d-amphetamine were determined before and after conditions of chronic treatment. When given before chronic treatment, d-amphetamine decreased both milk consumption and reinforcement received for lever-pressing in a dose-dependent manner. Subsequently, three conditions of chronic injection were established in which one group received saline, prior to both tasks, another group received d-amphetamine prior to drinking milk and saline prior to lever-pressing and the third group received d-amphetamine prior to lever-pressing and saline before drinking milk. The rats became tolerant to d-amphetamine in the task in which the drug had been administered chronically; however, the same rats showed no tolerance in the other task in which saline had been administered chronically. Tolerance to d-amphetamine was thus shown to be behaviorally specific.
KW - behavioral tolerance
KW - d-amphetamine
KW - operant behavior
KW - tolerance
UR - http://www.scopus.com/inward/record.url?scp=0021238474&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(84)90030-3
DO - 10.1016/0028-3908(84)90030-3
M3 - Article
C2 - 6738825
AN - SCOPUS:0021238474
VL - 23
SP - 563
EP - 568
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 5
ER -