Targeting Strategies for Tissue-Specific Drug Delivery

Zongmin Zhao, Anvay Ukidve, Jayoung Kim, Samir Mitragotri

Research output: Contribution to journalReview articlepeer-review

194 Scopus citations

Abstract

Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasing unwanted toxicities, and thereby enhancing a drug's therapeutic efficacy. Over the past three decades, a large body of literature has focused on understanding the biological barriers that hinder tissue-specific drug delivery and strategies to overcome them. These efforts have led to several targeting strategies that modulate drug delivery in both the preclinical and clinical settings, including small molecule-, nucleic acid-, peptide-, antibody-, and cell-based strategies. Here, we discuss key advances and emerging concepts for tissue-specific drug delivery approaches and their clinical translation.

Original languageEnglish
Pages (from-to)151-167
Number of pages17
JournalCell
Volume181
Issue number1
DOIs
StatePublished - 2 Apr 2020

Fingerprint

Dive into the research topics of 'Targeting Strategies for Tissue-Specific Drug Delivery'. Together they form a unique fingerprint.

Cite this