Targeting Strategies for Tissue-Specific Drug Delivery

Zongmin Zhao, Anvay Ukidve, Jayoung Kim, Samir Mitragotri

Research output: Contribution to journalReview articlepeer-review

225 Scopus citations


Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasing unwanted toxicities, and thereby enhancing a drug's therapeutic efficacy. Over the past three decades, a large body of literature has focused on understanding the biological barriers that hinder tissue-specific drug delivery and strategies to overcome them. These efforts have led to several targeting strategies that modulate drug delivery in both the preclinical and clinical settings, including small molecule-, nucleic acid-, peptide-, antibody-, and cell-based strategies. Here, we discuss key advances and emerging concepts for tissue-specific drug delivery approaches and their clinical translation.

Original languageEnglish
Pages (from-to)151-167
Number of pages17
Issue number1
StatePublished - 2 Apr 2020


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