Targeted nanoparticles for pediatric leukemia therapy

Riyaz Basha, Nirupama Sabnis, Kenneth Heym, W. Paul Bowman, Andras G. Lacko

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The two major forms of leukemia, acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), account for about one-third of the malignancies diagnosed in children. Despite the marked successes in ALL and AML treatment, concerns remain regarding the occurrence of resistant disease in subsets of patients, the residual effects of therapy that often persist for decades beyond the cessation of treatment. Therefore, new approaches are needed to reduce or to avoid offtarget toxicities, associated with chemotherapy and their long-term residual effects. Recently, nanotechnology has been employed to enhance cancer therapy, via improving the bioavailability and therapeutic efficacy of anti-cancer agents. While in the last several years, numerous review articles appeared detailing the size, composition, assembly, and performance evaluation of different types of drug carrying nanoparticles, the description and evaluation of lipoprotein-based drug carriers have been conspicuously absent from most of these major reviews. The current review focuses on such information regarding nanoparticles with an emphasis on high density lipoprotein-based drug delivery systems to examine their potential role(s) in the enhanced treatment of children with leukemia.

Original languageEnglish
Article number101
JournalFrontiers in Oncology
Volume4 MAY
DOIs
StatePublished - 2014

Keywords

  • Drug delivery systems
  • High density lipoprotein
  • Leukemia
  • Nanoparticles
  • Targeting

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