TY - JOUR
T1 - Synthesis of 2-(5-Bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors
AU - Mach, Robert H.
AU - Huang, Yunsheng
AU - Freeman, Rebekah A.
AU - Wu, Li
AU - Blair, Suwanna
AU - Luedtke, Robert R.
N1 - Funding Information:
This research was supported by PHS grants DA 09142, DA 09147 and DA 12647 from the National Institute on Drug Abuse.
PY - 2003/1/17
Y1 - 2003/1/17
N2 - A series of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues was prepared and their affinity for dopamine D2, D3, and D4 receptors was measured using in vitro binding assays. The results of receptor binding studies indicated that the incorporation of a pyrrole moiety between the phenyl ring and the basic nitrogen resulted in a significant increase in the selectivity for dopamine D3 receptors. The most selective compound in this series is 2-(5-bromo-2,3-dimethoxyphenyl)-5-(2-(3-pyridal)piperidinyl)methyl-1H-pyrrole (6p), which has a D3 receptor affinity of 4.3 nM, a 20-fold selectivity for D3 versus D2 receptors, and a 300-fold selectivity for D3 versus D4 receptors. This compound is predicted to be a useful ligand for studying the functional role of dopamine D3 receptors in vivo.
AB - A series of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues was prepared and their affinity for dopamine D2, D3, and D4 receptors was measured using in vitro binding assays. The results of receptor binding studies indicated that the incorporation of a pyrrole moiety between the phenyl ring and the basic nitrogen resulted in a significant increase in the selectivity for dopamine D3 receptors. The most selective compound in this series is 2-(5-bromo-2,3-dimethoxyphenyl)-5-(2-(3-pyridal)piperidinyl)methyl-1H-pyrrole (6p), which has a D3 receptor affinity of 4.3 nM, a 20-fold selectivity for D3 versus D2 receptors, and a 300-fold selectivity for D3 versus D4 receptors. This compound is predicted to be a useful ligand for studying the functional role of dopamine D3 receptors in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0037449354&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(02)00341-3
DO - 10.1016/S0968-0896(02)00341-3
M3 - Article
C2 - 12470717
AN - SCOPUS:0037449354
SN - 0968-0896
VL - 11
SP - 225
EP - 233
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 2
ER -