Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Yang I. Lin; Panayota Bitha; Subas M. Sakya; Stanley A. Lang; Youjun Yang; William J. Weiss; Peter J. Petersen; Karen Bush; Raymond T. Testa

doi:10.1016/S0960-894X(97)10143-3

Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Yang I. Lin, Panayota Bitha, Subas M. Sakya, Stanley A. Lang, Youjun Yang, William J. Weiss, Peter J. Petersen, Karen Bush, Raymond T. Testa

Research output: Contribution to journal › Article › peer-review

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Abstract

Two series of active aminomethyl-THF 1β-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa.

Original language	English
Pages (from-to)	3063-3068
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(97)10143-3
State	Published - 2 Dec 1997

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@article{20a4212bdb9d4f6ab89b0d0e3a97e2fc,

title = "Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II",

abstract = "Two series of active aminomethyl-THF 1β-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa.",

author = "Lin, {Yang I.} and Panayota Bitha and Sakya, {Subas M.} and Lang, {Stanley A.} and Youjun Yang and Weiss, {William J.} and Petersen, {Peter J.} and Karen Bush and Testa, {Raymond T.}",

year = "1997",

month = dec,

day = "2",

doi = "10.1016/S0960-894X(97)10143-3",

language = "English",

volume = "7",

pages = "3063--3068",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

AU - Lin, Yang I.

AU - Bitha, Panayota

AU - Sakya, Subas M.

AU - Lang, Stanley A.

AU - Yang, Youjun

AU - Weiss, William J.

AU - Petersen, Peter J.

AU - Bush, Karen

AU - Testa, Raymond T.

PY - 1997/12/2

Y1 - 1997/12/2

N2 - Two series of active aminomethyl-THF 1β-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa.

AB - Two series of active aminomethyl-THF 1β-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa.

UR - http://www.scopus.com/inward/record.url?scp=0030714181&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(97)10143-3

DO - 10.1016/S0960-894X(97)10143-3

M3 - Article

AN - SCOPUS:0030714181

SN - 0960-894X

VL - 7

SP - 3063

EP - 3068

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Abstract

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