Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Yang I. Lin, Panayota Bitha, Subas M. Sakya, Stanley A. Lang, Youjun Yang, William J. Weiss, Peter J. Petersen, Karen Bush, Raymond T. Testa

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Two series of active aminomethyl-THF 1β-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa.

Original languageEnglish
Pages (from-to)3063-3068
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number23
DOIs
StatePublished - 2 Dec 1997

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