Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II

Yang I. Lin, Panayota Bitha, Subas M. Sakya, Stanley A. Lang, Youjun Yang, William J. Weiss, Peter J. Petersen, Karen Bush, Raymond T. Testa

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Abstract

Two series of active aminomethyl-THF 1β-methylcarbapenem derivatives were synthesized. In general, they were all slightly less active than their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa.

Original languageEnglish
Pages (from-to)3063-3068
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number23
DOIs
StatePublished - 2 Dec 1997

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    Lin, Y. I., Bitha, P., Sakya, S. M., Lang, S. A., Yang, Y., Weiss, W. J., Petersen, P. J., Bush, K., & Testa, R. T. (1997). Synthesis and structure-activity relationship of novel THF 1β-methylcarbapenems II. Bioorganic and Medicinal Chemistry Letters, 7(23), 3063-3068. https://doi.org/10.1016/S0960-894X(97)10143-3