Abstract
Efficient synthetic routes to optically active analogues of lyngbyatoxin A, a potent activator of protein kinase C, have been devised starting from L-valine methyl ester. Access to the indole nucleus of these molecules is gained through the nitrile oxide based annelation of an aromatic ring to a pyrrole ring. The biological action of several of the intermediates and analogues prepared during the course of these studies on protein kinase C activity is also presented.
Original language | English |
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Pages (from-to) | 6228-6234 |
Number of pages | 7 |
Journal | Journal of the American Chemical Society |
Volume | 111 |
Issue number | 16 |
DOIs | |
State | Published - 1 Jan 1989 |