Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential

Zhong Alan Li, Shilpa Sant, Sung Kwon Cho, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Michael S. Gold, Hang Lin

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA), afflict a substantial proportion of the global population. However, current clinical management has not been focused on fully restoring the native function of joints. Organ-on-chip (OoC), also called a microphysiological system, which typically accommodates multiple human cell-derived tissues/organs under physiological culture conditions, is an emerging platform that potentially overcomes the limitations of current models in developing therapeutics. Herein, we review major steps in the generation of OoCs for studying arthritis, discuss the challenges faced when these novel platforms enter the next phase of development and application, and present the potential for OoC technology to investigate the pathogenesis of joint diseases and the development of efficacious therapies.

Original languageEnglish
Pages (from-to)511-527
Number of pages17
JournalTrends in Biotechnology
Issue number4
StatePublished - Apr 2023


  • arthritis
  • disease modeling
  • drug testing
  • joint disease
  • microphysiological system
  • personalized medicine


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