Abstract
Allele and genotype frequencies for 3 tetrameric short tandem repeat loci VWA, HUMTHO1, and F13A1 were determined in a Swiss population sample using multiplex PCR and subsequent electrophoresis in DNA sequencing gels processed by automated laser fluorescence detection. The technique allows single base pair resolution and rapid typing, with a concomitant reduction in the potential for human transcriptional typing errors. All loci meet Hardy-Weinberg expectations. In addition, there is little evidence for association of alleles among the 3 loci. The allelic frequency data can be used in forensic analyses and paternity tests to estimate the frequency of a multiple STR locus DNA profile in the Swiss population.
Original language | English |
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Pages (from-to) | 34-36 |
Number of pages | 3 |
Journal | International journal of legal medicine |
Volume | 107 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 1994 |
Keywords
- Fluorescence detection
- HUMTHO1 F13A1
- Hardy-Weinberg expectations
- Multiplex
- PCR
- Short tandem repeat loci
- VWA