Surface modification strategy based on the conjugation of NaYF 4 :5%Eu luminescent nanoprobe with organic aromatic compounds for application in bioimaging assays

Rodrigo da Silva Viana, Luciana Amaral de Mascena Costa, Andressa N.R. Leal, Tyrslai M. Williams, Liquian Luan, Guanyu Zhang, Maodie Wang, Ashlyn C. Harmon, Janaina V. dos Anjos, Rafael Cueto, Manoel Adrião Gomes Filho, Eduardo H.L. Falcão, Maria G.H. Vicente, Severino A. Junior, James Michael Mathis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Colon cancer is one of the world’s most deadly diseases. Because of its internal location, it is necessary to obtain faster and more efficient diagnostic tools for this organ site. In this context, we studied the development of new luminescent nanoprobes (LNPs) as an alternative diagnostic apparatus for detecting this disease. The nanoparticles examined herein are lanthanide-doped sodium yttrium fluoride (NaYF 4 :Ln) and have shown to be promising as investigative devices. However, significant problems with the use of LNPs are the lack of biocompatibility and the targeting of the system to tumor regions. One of the strategies to bypass these problems is to increase of the particle lipophilicity modifying their surfaces with organic compounds that present high similarity to the biological system. In this work, we synthesized six new materials for use in bioimaging techniques obtained from the combination of nanoparticles of NaYF 4 :5%Eu with organic aromatic compounds covalently bonded. The materials were characterized structurally and morphologically using XRD and TEM, techniques, which showed the identification of the crystallographic phase β-NaYF 4 :5%Eu and its nanometric size (particles smaller than 50 nm). The conjugation process was confirmed by FT-IR spectra analysis and from the TGA profile. Excitation and emission spectra allowed the evaluation of the optical properties of the synthesized compounds. The interaction and cellular uptake was confirmed when HT-29 colon cancer cells were exposed to LNPs, indicating that the developed system has promising applications in bioimaging procedures. [Figure not available: see fulltext.].

Original languageEnglish
Article number23
JournalJournal of Nanoparticle Research
Volume21
Issue number1
DOIs
StatePublished - 1 Jan 2019

Fingerprint

Nanoprobes
Surface Modification
aromatic compounds
Aromatic compounds
Conjugation
conjugation
Nanoparticles
Surface treatment
Assays
Diagnostics
Cancer
cancer
nanoparticles
Spectrum Analysis
bypasses
biocompatibility
yttrium
organic compounds
Particle Size
Biological Systems

Keywords

  • Cell imaging
  • Couple reaction
  • Diagnostic tool
  • Luminescent nanoprobe
  • NaYF :5%Eu
  • Surface conjugation

Cite this

da Silva Viana, Rodrigo ; de Mascena Costa, Luciana Amaral ; Leal, Andressa N.R. ; Williams, Tyrslai M. ; Luan, Liquian ; Zhang, Guanyu ; Wang, Maodie ; Harmon, Ashlyn C. ; dos Anjos, Janaina V. ; Cueto, Rafael ; Filho, Manoel Adrião Gomes ; Falcão, Eduardo H.L. ; Vicente, Maria G.H. ; Junior, Severino A. ; Mathis, James Michael. / Surface modification strategy based on the conjugation of NaYF 4 :5%Eu luminescent nanoprobe with organic aromatic compounds for application in bioimaging assays In: Journal of Nanoparticle Research. 2019 ; Vol. 21, No. 1.
@article{d196e240ddd741ca8574d0c5cb0927cf,
title = "Surface modification strategy based on the conjugation of NaYF 4 :5{\%}Eu luminescent nanoprobe with organic aromatic compounds for application in bioimaging assays",
abstract = "Colon cancer is one of the world’s most deadly diseases. Because of its internal location, it is necessary to obtain faster and more efficient diagnostic tools for this organ site. In this context, we studied the development of new luminescent nanoprobes (LNPs) as an alternative diagnostic apparatus for detecting this disease. The nanoparticles examined herein are lanthanide-doped sodium yttrium fluoride (NaYF 4 :Ln) and have shown to be promising as investigative devices. However, significant problems with the use of LNPs are the lack of biocompatibility and the targeting of the system to tumor regions. One of the strategies to bypass these problems is to increase of the particle lipophilicity modifying their surfaces with organic compounds that present high similarity to the biological system. In this work, we synthesized six new materials for use in bioimaging techniques obtained from the combination of nanoparticles of NaYF 4 :5{\%}Eu with organic aromatic compounds covalently bonded. The materials were characterized structurally and morphologically using XRD and TEM, techniques, which showed the identification of the crystallographic phase β-NaYF 4 :5{\%}Eu and its nanometric size (particles smaller than 50 nm). The conjugation process was confirmed by FT-IR spectra analysis and from the TGA profile. Excitation and emission spectra allowed the evaluation of the optical properties of the synthesized compounds. The interaction and cellular uptake was confirmed when HT-29 colon cancer cells were exposed to LNPs, indicating that the developed system has promising applications in bioimaging procedures. [Figure not available: see fulltext.].",
keywords = "Cell imaging, Couple reaction, Diagnostic tool, Luminescent nanoprobe, NaYF :5{\%}Eu, Surface conjugation",
author = "{da Silva Viana}, Rodrigo and {de Mascena Costa}, {Luciana Amaral} and Leal, {Andressa N.R.} and Williams, {Tyrslai M.} and Liquian Luan and Guanyu Zhang and Maodie Wang and Harmon, {Ashlyn C.} and {dos Anjos}, {Janaina V.} and Rafael Cueto and Filho, {Manoel Adri{\~a}o Gomes} and Falc{\~a}o, {Eduardo H.L.} and Vicente, {Maria G.H.} and Junior, {Severino A.} and Mathis, {James Michael}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11051-018-4422-0",
language = "English",
volume = "21",
journal = "Journal of Nanoparticle Research",
issn = "1388-0764",
publisher = "Springer Netherlands",
number = "1",

}

da Silva Viana, R, de Mascena Costa, LA, Leal, ANR, Williams, TM, Luan, L, Zhang, G, Wang, M, Harmon, AC, dos Anjos, JV, Cueto, R, Filho, MAG, Falcão, EHL, Vicente, MGH, Junior, SA & Mathis, JM 2019, ' Surface modification strategy based on the conjugation of NaYF 4 :5%Eu luminescent nanoprobe with organic aromatic compounds for application in bioimaging assays ', Journal of Nanoparticle Research, vol. 21, no. 1, 23. https://doi.org/10.1007/s11051-018-4422-0

Surface modification strategy based on the conjugation of NaYF 4 :5%Eu luminescent nanoprobe with organic aromatic compounds for application in bioimaging assays . / da Silva Viana, Rodrigo; de Mascena Costa, Luciana Amaral; Leal, Andressa N.R.; Williams, Tyrslai M.; Luan, Liquian; Zhang, Guanyu; Wang, Maodie; Harmon, Ashlyn C.; dos Anjos, Janaina V.; Cueto, Rafael; Filho, Manoel Adrião Gomes; Falcão, Eduardo H.L.; Vicente, Maria G.H.; Junior, Severino A.; Mathis, James Michael.

In: Journal of Nanoparticle Research, Vol. 21, No. 1, 23, 01.01.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Surface modification strategy based on the conjugation of NaYF 4 :5%Eu luminescent nanoprobe with organic aromatic compounds for application in bioimaging assays

AU - da Silva Viana, Rodrigo

AU - de Mascena Costa, Luciana Amaral

AU - Leal, Andressa N.R.

AU - Williams, Tyrslai M.

AU - Luan, Liquian

AU - Zhang, Guanyu

AU - Wang, Maodie

AU - Harmon, Ashlyn C.

AU - dos Anjos, Janaina V.

AU - Cueto, Rafael

AU - Filho, Manoel Adrião Gomes

AU - Falcão, Eduardo H.L.

AU - Vicente, Maria G.H.

AU - Junior, Severino A.

AU - Mathis, James Michael

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Colon cancer is one of the world’s most deadly diseases. Because of its internal location, it is necessary to obtain faster and more efficient diagnostic tools for this organ site. In this context, we studied the development of new luminescent nanoprobes (LNPs) as an alternative diagnostic apparatus for detecting this disease. The nanoparticles examined herein are lanthanide-doped sodium yttrium fluoride (NaYF 4 :Ln) and have shown to be promising as investigative devices. However, significant problems with the use of LNPs are the lack of biocompatibility and the targeting of the system to tumor regions. One of the strategies to bypass these problems is to increase of the particle lipophilicity modifying their surfaces with organic compounds that present high similarity to the biological system. In this work, we synthesized six new materials for use in bioimaging techniques obtained from the combination of nanoparticles of NaYF 4 :5%Eu with organic aromatic compounds covalently bonded. The materials were characterized structurally and morphologically using XRD and TEM, techniques, which showed the identification of the crystallographic phase β-NaYF 4 :5%Eu and its nanometric size (particles smaller than 50 nm). The conjugation process was confirmed by FT-IR spectra analysis and from the TGA profile. Excitation and emission spectra allowed the evaluation of the optical properties of the synthesized compounds. The interaction and cellular uptake was confirmed when HT-29 colon cancer cells were exposed to LNPs, indicating that the developed system has promising applications in bioimaging procedures. [Figure not available: see fulltext.].

AB - Colon cancer is one of the world’s most deadly diseases. Because of its internal location, it is necessary to obtain faster and more efficient diagnostic tools for this organ site. In this context, we studied the development of new luminescent nanoprobes (LNPs) as an alternative diagnostic apparatus for detecting this disease. The nanoparticles examined herein are lanthanide-doped sodium yttrium fluoride (NaYF 4 :Ln) and have shown to be promising as investigative devices. However, significant problems with the use of LNPs are the lack of biocompatibility and the targeting of the system to tumor regions. One of the strategies to bypass these problems is to increase of the particle lipophilicity modifying their surfaces with organic compounds that present high similarity to the biological system. In this work, we synthesized six new materials for use in bioimaging techniques obtained from the combination of nanoparticles of NaYF 4 :5%Eu with organic aromatic compounds covalently bonded. The materials were characterized structurally and morphologically using XRD and TEM, techniques, which showed the identification of the crystallographic phase β-NaYF 4 :5%Eu and its nanometric size (particles smaller than 50 nm). The conjugation process was confirmed by FT-IR spectra analysis and from the TGA profile. Excitation and emission spectra allowed the evaluation of the optical properties of the synthesized compounds. The interaction and cellular uptake was confirmed when HT-29 colon cancer cells were exposed to LNPs, indicating that the developed system has promising applications in bioimaging procedures. [Figure not available: see fulltext.].

KW - Cell imaging

KW - Couple reaction

KW - Diagnostic tool

KW - Luminescent nanoprobe

KW - NaYF :5%Eu

KW - Surface conjugation

UR - http://www.scopus.com/inward/record.url?scp=85060916728&partnerID=8YFLogxK

U2 - 10.1007/s11051-018-4422-0

DO - 10.1007/s11051-018-4422-0

M3 - Article

VL - 21

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

SN - 1388-0764

IS - 1

M1 - 23

ER -