[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Keila Isaac-Olivé, Blanca E. Ocampo-García, Liliana Aranda-Lara, Clara L. Santos-Cuevas, Nallely P. Jiménez-Mancilla, Myrna A. Luna-Gutiérrez, Luis A. Medina, Bhavani Nagarajan, Nirupama Sabnis, Sangram Raut, Laszlo Prokai, Andras G. Lacko

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2 Scopus citations

Abstract

Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems have received only limited attention so far. These studies involve the synthesis of a novel hydrophobic radio-imaging tracer consisting of a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99 mTc conjugate that can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in vivo. We provide details of the tracer synthesis, characterization of the rHDL/tracer complex, in vitro uptake, stability studies and in vivo application of this new radio-imaging approach.

Original languageEnglish
Pages (from-to)541-551
Number of pages11
JournalNanoscale
Volume11
Issue number2
DOIs
StatePublished - 14 Jan 2019

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    Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S., Prokai, L., & Lacko, A. G. (2019). [ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging Nanoscale, 11(2), 541-551. https://doi.org/10.1039/c8nr07484d