Abstract
HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino- 9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [13C]acetate into HC-toxin was studied using NMR. The pattern of incorporation of 13C was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.
Original language | English |
---|---|
Pages (from-to) | 143-145 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 62 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 1999 |