13C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate

Yiqiang Cheng, Long Dinh Le, Jonathan D. Walton, Karl D. Bishop

Research output: Contribution to journalArticle

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Abstract

HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino- 9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [13C]acetate into HC-toxin was studied using NMR. The pattern of incorporation of 13C was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalJournal of Natural Products
Volume62
Issue number1
DOIs
StatePublished - 1 Jan 1999

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