13C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate

Yiqiang Cheng; Long Dinh Le; Jonathan D. Walton; Karl D. Bishop

doi:10.1021/np980209e

¹³C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate

Yiqiang Cheng, Long Dinh Le, Jonathan D. Walton, Karl D. Bishop

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino- 9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [¹³C]acetate into HC-toxin was studied using NMR. The pattern of incorporation of ¹³C was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.

Original language	English
Pages (from-to)	143-145
Number of pages	3
Journal	Journal of Natural Products
Volume	62
Issue number	1
DOIs	https://doi.org/10.1021/np980209e
State	Published - 1 Jan 1999

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title = "13C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate",

abstract = "HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino- 9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [13C]acetate into HC-toxin was studied using NMR. The pattern of incorporation of 13C was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.",

author = "Yiqiang Cheng and Le, {Long Dinh} and Walton, {Jonathan D.} and Bishop, {Karl D.}",

year = "1999",

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T1 - 13C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate

AU - Cheng, Yiqiang

AU - Le, Long Dinh

AU - Walton, Jonathan D.

AU - Bishop, Karl D.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino- 9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [13C]acetate into HC-toxin was studied using NMR. The pattern of incorporation of 13C was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.

AB - HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino- 9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [13C]acetate into HC-toxin was studied using NMR. The pattern of incorporation of 13C was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

¹³C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate

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