TY - JOUR
T1 - Subunit molecular weight and genetic variability of proteins in natural populations
AU - Nei, M.
AU - Fuerst, P. A.
AU - Chakraborty, R.
PY - 1978
Y1 - 1978
N2 - The relationship between subunit molecular weight and heterozygosity was studied in six different groups of organisms, i.e., 9 species of primates, 32 species of rodents, 56 species of reptiles, 12 species of salamanders, 64 species of teleost fishes, and 29 species of Drosophila. The correlation coefficient between them was positive in all groups, and the magnitude of correlation was roughly in agreement with the theoretical expectation under the mutation-drift hypothesis when the incomplete correlation between molecular weight and mutation rate was taken into account. Furthermore, the correlation was higher when the average heterozygosity was high than when this was low, as theoretically expected.
AB - The relationship between subunit molecular weight and heterozygosity was studied in six different groups of organisms, i.e., 9 species of primates, 32 species of rodents, 56 species of reptiles, 12 species of salamanders, 64 species of teleost fishes, and 29 species of Drosophila. The correlation coefficient between them was positive in all groups, and the magnitude of correlation was roughly in agreement with the theoretical expectation under the mutation-drift hypothesis when the incomplete correlation between molecular weight and mutation rate was taken into account. Furthermore, the correlation was higher when the average heterozygosity was high than when this was low, as theoretically expected.
UR - http://www.scopus.com/inward/record.url?scp=0018143510&partnerID=8YFLogxK
U2 - 10.1073/pnas.75.7.3359
DO - 10.1073/pnas.75.7.3359
M3 - Article
C2 - 277936
AN - SCOPUS:0018143510
SN - 0027-8424
VL - 75
SP - 3359
EP - 3362
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -