Subunit molecular weight and genetic variability of proteins in natural populations

M. Nei, P. A. Fuerst, Ranajit Chakraborty

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

The relationship between subunit molecular weight and heterozygosity was studied in six different groups of organisms, i.e., 9 species of primates, 32 species of rodents, 56 species of reptiles, 12 species of salamanders, 64 species of teleost fishes, and 29 species of Drosophila. The correlation coefficient between them was positive in all groups, and the magnitude of correlation was roughly in agreement with the theoretical expectation under the mutation-drift hypothesis when the incomplete correlation between molecular weight and mutation rate was taken into account. Furthermore, the correlation was higher when the average heterozygosity was high than when this was low, as theoretically expected.

Original languageEnglish
Pages (from-to)3359-3362
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number7
DOIs
StatePublished - 1 Jan 1978

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Molecular Biology
Molecular Weight
Urodela
Reptiles
Mutation Rate
Primates
Population
Drosophila
Rodentia
Fishes
Proteins
Mutation

Cite this

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Subunit molecular weight and genetic variability of proteins in natural populations. / Nei, M.; Fuerst, P. A.; Chakraborty, Ranajit.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 75, No. 7, 01.01.1978, p. 3359-3362.

Research output: Contribution to journalArticleResearchpeer-review

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