Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage

Jincheng Wang, Haoli Xu, Shuailiang Liu, Yue Zhang, Jinjin Liu, Wenwen He, Xiaotao Qin, Yunjun Yang, Qichuan Zhuge, Kunlin Jin, Weijian Chen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To investigate alterations of permeability of surface (PS) in subacute stage patients with intracerebral hemorrhage (ICH) using computed tomography perfusion imaging (CTPI), and analyze relationships between PS and other factors. Methods: CTPI was performed in 35 patients in subacute stage (4 days-2 weeks) after onset of ICH, who were recruited in the Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from November 2015 to June 2016. Hematoma and edema volumes were measured, and perfusion parameters of perihematoma and mirror hemisphere side of marginal zone and outer zone of hematoma, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), PS, and relative value (ipsilateral/contralateral) of CBF (rCBF), CBV (rCBV), MTT (rMTT) and PS (rPS), were calculated. Relationships between volumes of hematoma and edema, time from onset to CTPI performance, NIHSS scores and PS of perihematoma zone were analyzed by Pearson correlation analysis. Results: The perihematoma PS ((1.87±0.48) ml·100 g-1·min-1) was higher than that in contralateral regions ((1.28±0.34) ml·100 g-1·min-1;t=-12.407, P<0.01). Meanwhile, there was a statistically significant difference between rPS in proximal area (1.81±0.50) and rPS in outer area (1.04±0.21) (t=7.936, P<0.001). The absolute value of perihematoma PS had a positive correlation with the time from onset to CTPI performance (r=0.507, P<0.05). But there were no statistically significant correlations between perihematoma PS and volumes of hematoma or edema (both P>0.05). There were 20 patients with hematoma volume less than 10 ml and 15 patients with hematoma volume more than 10 ml, while the mean value of perihematoma PS of them showed no statistically significant difference (P>0.05). And there were no statistically significant correlations between perihematoma PS and NIHSS scores at the time of admission, CTPI examination and discharge (all P>0.05). Conclusions: In subacute stage of ICH, the blood brain barrier permeability of perihematoma area is still abnormal, manifested as PS increases. The perihematoma PS positively correlates with the time of ICH onset. CTPI can accurately reflect this change, and potentially provide valuable information for evaluation and individual treatment of patients.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalChinese Journal of Neurology
Volume50
Issue number3
DOIs
StatePublished - 8 Mar 2017

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Cerebral Hemorrhage
Basal Ganglia
Permeability
Perfusion
Perfusion Imaging
Hematoma
Tomography
Cerebrovascular Circulation
Edema
Neurology
Blood-Brain Barrier

Keywords

  • Capillary permeability
  • Intracerebral hemorrhage
  • Perfusion
  • Subacute stage
  • Tomography, X-ray computed

Cite this

Wang, Jincheng ; Xu, Haoli ; Liu, Shuailiang ; Zhang, Yue ; Liu, Jinjin ; He, Wenwen ; Qin, Xiaotao ; Yang, Yunjun ; Zhuge, Qichuan ; Jin, Kunlin ; Chen, Weijian. / Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage. In: Chinese Journal of Neurology. 2017 ; Vol. 50, No. 3. pp. 201-207.
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title = "Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage",
abstract = "Objective: To investigate alterations of permeability of surface (PS) in subacute stage patients with intracerebral hemorrhage (ICH) using computed tomography perfusion imaging (CTPI), and analyze relationships between PS and other factors. Methods: CTPI was performed in 35 patients in subacute stage (4 days-2 weeks) after onset of ICH, who were recruited in the Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from November 2015 to June 2016. Hematoma and edema volumes were measured, and perfusion parameters of perihematoma and mirror hemisphere side of marginal zone and outer zone of hematoma, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), PS, and relative value (ipsilateral/contralateral) of CBF (rCBF), CBV (rCBV), MTT (rMTT) and PS (rPS), were calculated. Relationships between volumes of hematoma and edema, time from onset to CTPI performance, NIHSS scores and PS of perihematoma zone were analyzed by Pearson correlation analysis. Results: The perihematoma PS ((1.87±0.48) ml·100 g-1·min-1) was higher than that in contralateral regions ((1.28±0.34) ml·100 g-1·min-1;t=-12.407, P<0.01). Meanwhile, there was a statistically significant difference between rPS in proximal area (1.81±0.50) and rPS in outer area (1.04±0.21) (t=7.936, P<0.001). The absolute value of perihematoma PS had a positive correlation with the time from onset to CTPI performance (r=0.507, P<0.05). But there were no statistically significant correlations between perihematoma PS and volumes of hematoma or edema (both P>0.05). There were 20 patients with hematoma volume less than 10 ml and 15 patients with hematoma volume more than 10 ml, while the mean value of perihematoma PS of them showed no statistically significant difference (P>0.05). And there were no statistically significant correlations between perihematoma PS and NIHSS scores at the time of admission, CTPI examination and discharge (all P>0.05). Conclusions: In subacute stage of ICH, the blood brain barrier permeability of perihematoma area is still abnormal, manifested as PS increases. The perihematoma PS positively correlates with the time of ICH onset. CTPI can accurately reflect this change, and potentially provide valuable information for evaluation and individual treatment of patients.",
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author = "Jincheng Wang and Haoli Xu and Shuailiang Liu and Yue Zhang and Jinjin Liu and Wenwen He and Xiaotao Qin and Yunjun Yang and Qichuan Zhuge and Kunlin Jin and Weijian Chen",
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Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage. / Wang, Jincheng; Xu, Haoli; Liu, Shuailiang; Zhang, Yue; Liu, Jinjin; He, Wenwen; Qin, Xiaotao; Yang, Yunjun; Zhuge, Qichuan; Jin, Kunlin; Chen, Weijian.

In: Chinese Journal of Neurology, Vol. 50, No. 3, 08.03.2017, p. 201-207.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage

AU - Wang, Jincheng

AU - Xu, Haoli

AU - Liu, Shuailiang

AU - Zhang, Yue

AU - Liu, Jinjin

AU - He, Wenwen

AU - Qin, Xiaotao

AU - Yang, Yunjun

AU - Zhuge, Qichuan

AU - Jin, Kunlin

AU - Chen, Weijian

PY - 2017/3/8

Y1 - 2017/3/8

N2 - Objective: To investigate alterations of permeability of surface (PS) in subacute stage patients with intracerebral hemorrhage (ICH) using computed tomography perfusion imaging (CTPI), and analyze relationships between PS and other factors. Methods: CTPI was performed in 35 patients in subacute stage (4 days-2 weeks) after onset of ICH, who were recruited in the Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from November 2015 to June 2016. Hematoma and edema volumes were measured, and perfusion parameters of perihematoma and mirror hemisphere side of marginal zone and outer zone of hematoma, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), PS, and relative value (ipsilateral/contralateral) of CBF (rCBF), CBV (rCBV), MTT (rMTT) and PS (rPS), were calculated. Relationships between volumes of hematoma and edema, time from onset to CTPI performance, NIHSS scores and PS of perihematoma zone were analyzed by Pearson correlation analysis. Results: The perihematoma PS ((1.87±0.48) ml·100 g-1·min-1) was higher than that in contralateral regions ((1.28±0.34) ml·100 g-1·min-1;t=-12.407, P<0.01). Meanwhile, there was a statistically significant difference between rPS in proximal area (1.81±0.50) and rPS in outer area (1.04±0.21) (t=7.936, P<0.001). The absolute value of perihematoma PS had a positive correlation with the time from onset to CTPI performance (r=0.507, P<0.05). But there were no statistically significant correlations between perihematoma PS and volumes of hematoma or edema (both P>0.05). There were 20 patients with hematoma volume less than 10 ml and 15 patients with hematoma volume more than 10 ml, while the mean value of perihematoma PS of them showed no statistically significant difference (P>0.05). And there were no statistically significant correlations between perihematoma PS and NIHSS scores at the time of admission, CTPI examination and discharge (all P>0.05). Conclusions: In subacute stage of ICH, the blood brain barrier permeability of perihematoma area is still abnormal, manifested as PS increases. The perihematoma PS positively correlates with the time of ICH onset. CTPI can accurately reflect this change, and potentially provide valuable information for evaluation and individual treatment of patients.

AB - Objective: To investigate alterations of permeability of surface (PS) in subacute stage patients with intracerebral hemorrhage (ICH) using computed tomography perfusion imaging (CTPI), and analyze relationships between PS and other factors. Methods: CTPI was performed in 35 patients in subacute stage (4 days-2 weeks) after onset of ICH, who were recruited in the Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from November 2015 to June 2016. Hematoma and edema volumes were measured, and perfusion parameters of perihematoma and mirror hemisphere side of marginal zone and outer zone of hematoma, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), PS, and relative value (ipsilateral/contralateral) of CBF (rCBF), CBV (rCBV), MTT (rMTT) and PS (rPS), were calculated. Relationships between volumes of hematoma and edema, time from onset to CTPI performance, NIHSS scores and PS of perihematoma zone were analyzed by Pearson correlation analysis. Results: The perihematoma PS ((1.87±0.48) ml·100 g-1·min-1) was higher than that in contralateral regions ((1.28±0.34) ml·100 g-1·min-1;t=-12.407, P<0.01). Meanwhile, there was a statistically significant difference between rPS in proximal area (1.81±0.50) and rPS in outer area (1.04±0.21) (t=7.936, P<0.001). The absolute value of perihematoma PS had a positive correlation with the time from onset to CTPI performance (r=0.507, P<0.05). But there were no statistically significant correlations between perihematoma PS and volumes of hematoma or edema (both P>0.05). There were 20 patients with hematoma volume less than 10 ml and 15 patients with hematoma volume more than 10 ml, while the mean value of perihematoma PS of them showed no statistically significant difference (P>0.05). And there were no statistically significant correlations between perihematoma PS and NIHSS scores at the time of admission, CTPI examination and discharge (all P>0.05). Conclusions: In subacute stage of ICH, the blood brain barrier permeability of perihematoma area is still abnormal, manifested as PS increases. The perihematoma PS positively correlates with the time of ICH onset. CTPI can accurately reflect this change, and potentially provide valuable information for evaluation and individual treatment of patients.

KW - Capillary permeability

KW - Intracerebral hemorrhage

KW - Perfusion

KW - Subacute stage

KW - Tomography, X-ray computed

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U2 - 10.3760/cma.j.issn.1006-7876.2017.03.009

DO - 10.3760/cma.j.issn.1006-7876.2017.03.009

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JO - Chinese Journal of Neurology

JF - Chinese Journal of Neurology

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