Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage

Jincheng Wang, Haoli Xu, Shuailiang Liu, Yue Zhang, Jinjin Liu, Wenwen He, Xiaotao Qin, Yunjun Yang, Qichuan Zhuge, Kunlin Jin, Weijian Chen

Research output: Contribution to journalArticle

Abstract

Objective: To investigate alterations of permeability of surface (PS) in subacute stage patients with intracerebral hemorrhage (ICH) using computed tomography perfusion imaging (CTPI), and analyze relationships between PS and other factors. Methods: CTPI was performed in 35 patients in subacute stage (4 days-2 weeks) after onset of ICH, who were recruited in the Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from November 2015 to June 2016. Hematoma and edema volumes were measured, and perfusion parameters of perihematoma and mirror hemisphere side of marginal zone and outer zone of hematoma, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), PS, and relative value (ipsilateral/contralateral) of CBF (rCBF), CBV (rCBV), MTT (rMTT) and PS (rPS), were calculated. Relationships between volumes of hematoma and edema, time from onset to CTPI performance, NIHSS scores and PS of perihematoma zone were analyzed by Pearson correlation analysis. Results: The perihematoma PS ((1.87±0.48) ml·100 g-1·min-1) was higher than that in contralateral regions ((1.28±0.34) ml·100 g-1·min-1;t=-12.407, P<0.01). Meanwhile, there was a statistically significant difference between rPS in proximal area (1.81±0.50) and rPS in outer area (1.04±0.21) (t=7.936, P<0.001). The absolute value of perihematoma PS had a positive correlation with the time from onset to CTPI performance (r=0.507, P<0.05). But there were no statistically significant correlations between perihematoma PS and volumes of hematoma or edema (both P>0.05). There were 20 patients with hematoma volume less than 10 ml and 15 patients with hematoma volume more than 10 ml, while the mean value of perihematoma PS of them showed no statistically significant difference (P>0.05). And there were no statistically significant correlations between perihematoma PS and NIHSS scores at the time of admission, CTPI examination and discharge (all P>0.05). Conclusions: In subacute stage of ICH, the blood brain barrier permeability of perihematoma area is still abnormal, manifested as PS increases. The perihematoma PS positively correlates with the time of ICH onset. CTPI can accurately reflect this change, and potentially provide valuable information for evaluation and individual treatment of patients.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalChinese Journal of Neurology
Volume50
Issue number3
DOIs
StatePublished - 8 Mar 2017

Keywords

  • Capillary permeability
  • Intracerebral hemorrhage
  • Perfusion
  • Subacute stage
  • Tomography, X-ray computed

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