Abstract
K + contractures were induced in paired strips of rabbit aortic smooth muscle. The relationship between relaxant effects and the bath concentration of hydralazine acetone hydrazone (HA), 4-OH-hydralazine (HH) and phthalazine (P) was studied over the concentration range 10 -5 - 10 -3 M. All compounds were active, HA = HH > P (p < 0.05; n = 6) at concentrations in the range 10 -4 - 10 -3 M, HA > HH at a concentration of 10 -3M (p > 0.01). The activity of HA did not depend on significant reconversion to hydralazine (H) in the bath (< 0.5%). A range of H derivatives may contribute to the hypotensive effects of administered H.
| Original language | English |
|---|---|
| Pages (from-to) | 19-25 |
| Number of pages | 7 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 235 |
| Issue number | 1 |
| State | Published - 1 Dec 1978 |
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Study of in vitro effects of hydralazine metabolites - Comparative evaluation of products of hydroxylation, hydrolysis and conjugation. / McLean, A. J.; du Souich, P.; Barron, Kirk; Carrier, O.; Haegele, K. D.; McNay, J. L.
In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 235, No. 1, 01.12.1978, p. 19-25.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Study of in vitro effects of hydralazine metabolites - Comparative evaluation of products of hydroxylation, hydrolysis and conjugation
AU - McLean, A. J.
AU - du Souich, P.
AU - Barron, Kirk
AU - Carrier, O.
AU - Haegele, K. D.
AU - McNay, J. L.
PY - 1978/12/1
Y1 - 1978/12/1
N2 - K + contractures were induced in paired strips of rabbit aortic smooth muscle. The relationship between relaxant effects and the bath concentration of hydralazine acetone hydrazone (HA), 4-OH-hydralazine (HH) and phthalazine (P) was studied over the concentration range 10 -5 - 10 -3 M. All compounds were active, HA = HH > P (p < 0.05; n = 6) at concentrations in the range 10 -4 - 10 -3 M, HA > HH at a concentration of 10 -3M (p > 0.01). The activity of HA did not depend on significant reconversion to hydralazine (H) in the bath (< 0.5%). A range of H derivatives may contribute to the hypotensive effects of administered H.
AB - K + contractures were induced in paired strips of rabbit aortic smooth muscle. The relationship between relaxant effects and the bath concentration of hydralazine acetone hydrazone (HA), 4-OH-hydralazine (HH) and phthalazine (P) was studied over the concentration range 10 -5 - 10 -3 M. All compounds were active, HA = HH > P (p < 0.05; n = 6) at concentrations in the range 10 -4 - 10 -3 M, HA > HH at a concentration of 10 -3M (p > 0.01). The activity of HA did not depend on significant reconversion to hydralazine (H) in the bath (< 0.5%). A range of H derivatives may contribute to the hypotensive effects of administered H.
UR - http://www.scopus.com/inward/record.url?scp=0018074522&partnerID=8YFLogxK
M3 - Article
VL - 235
SP - 19
EP - 25
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
SN - 0003-9780
IS - 1
ER -