Abstract
K + contractures were induced in paired strips of rabbit aortic smooth muscle. The relationship between relaxant effects and the bath concentration of hydralazine acetone hydrazone (HA), 4-OH-hydralazine (HH) and phthalazine (P) was studied over the concentration range 10 -5 - 10 -3 M. All compounds were active, HA = HH > P (p < 0.05; n = 6) at concentrations in the range 10 -4 - 10 -3 M, HA > HH at a concentration of 10 -3M (p > 0.01). The activity of HA did not depend on significant reconversion to hydralazine (H) in the bath (< 0.5%). A range of H derivatives may contribute to the hypotensive effects of administered H.
Original language | English |
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Pages (from-to) | 19-25 |
Number of pages | 7 |
Journal | Archives Internationales de Pharmacodynamie et de Therapie |
Volume | 235 |
Issue number | 1 |
State | Published - 1 Dec 1978 |