Studies on solvatochromic properties of aminophenylstyryl-quinolinum dye, LDS 798, and its application in studying submicron lipid based structure

Pabak Sarkar, Rafal Luchowski, Sangram Limbaji Raut, Nirupama Sabnis, Alan Remaley, Andras G. Lacko, Sanjay Thamake, Zygmunt Gryczynski, Ignacy Gryczynski

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The styryl group of dyes has been used in cellular studies for over 20 years because of their solvatochromic and/or electrochromic properties. Here we report characterization of solubility and solvatochromic properties of a near infra-red styryl dye, styryl 11 or LDS 798. We have extended our studies to small unilamellar vesicles and lipid based nanoparticles and found that solvatochromic properties of this dye used in tandem with fluorescence correlation spectroscopy can be used to efficiently determine the diffusion coefficient and hence the size of the submicron lipid based particles. This technique has the potential to provide essential information about liposomal and vesicular structures and their movement in vitro and in situ.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalBiophysical Chemistry
Volume153
Issue number1
DOIs
StatePublished - 1 Dec 2010

Keywords

  • Aminostyryl quinolinum dye
  • Fluorescence correlation Spectroscopy
  • Solvatochromism

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