Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds

Laszlo Prokai; James W. Simpkins

doi:10.1016/j.pharmthera.2007.01.006

Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds

Laszlo Prokai, James W. Simpkins

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Nongenomic estrogen signaling pathways involve extranuclear estrogen receptors or function independently from estrogen receptors. These pathways participate in neuroprotection elicited by the hormone. Additional nongenomic neuroprotective effects are attributable to antioxidant and antiinflammatory actions of estrogens. Numerous chemical modifications to afford neuroprotective compounds from estrogens while eliminating estrogenicity and maintaining or enhancing nongenomic neuroprotection have been described. This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Pharmacology and Therapeutics
Volume	114
Issue number	1
DOIs	https://doi.org/10.1016/j.pharmthera.2007.01.006
State	Published - Apr 2007

Keywords

Antioxidant
Estrogen
Neuroprotection
Nongenomic mechanism

Access to Document

10.1016/j.pharmthera.2007.01.006

Cite this

@article{6fa3ce50341149a4a28a5a18a2930f40,

title = "Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds",

abstract = "Nongenomic estrogen signaling pathways involve extranuclear estrogen receptors or function independently from estrogen receptors. These pathways participate in neuroprotection elicited by the hormone. Additional nongenomic neuroprotective effects are attributable to antioxidant and antiinflammatory actions of estrogens. Numerous chemical modifications to afford neuroprotective compounds from estrogens while eliminating estrogenicity and maintaining or enhancing nongenomic neuroprotection have been described. This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives.",

keywords = "Antioxidant, Estrogen, Neuroprotection, Nongenomic mechanism",

author = "Laszlo Prokai and Simpkins, {James W.}",

note = "Funding Information: This work was supported by the NIH grant NS044765 and an endowment from the Welch Foundation to L.P., and the NIH grants AG010485 and AG022550 to J.W.S.",

year = "2007",

month = apr,

doi = "10.1016/j.pharmthera.2007.01.006",

language = "English",

volume = "114",

pages = "1--12",

journal = "Pharmacology and Therapeutics",

issn = "0163-7258",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds

AU - Prokai, Laszlo

AU - Simpkins, James W.

N1 - Funding Information: This work was supported by the NIH grant NS044765 and an endowment from the Welch Foundation to L.P., and the NIH grants AG010485 and AG022550 to J.W.S.

PY - 2007/4

Y1 - 2007/4

N2 - Nongenomic estrogen signaling pathways involve extranuclear estrogen receptors or function independently from estrogen receptors. These pathways participate in neuroprotection elicited by the hormone. Additional nongenomic neuroprotective effects are attributable to antioxidant and antiinflammatory actions of estrogens. Numerous chemical modifications to afford neuroprotective compounds from estrogens while eliminating estrogenicity and maintaining or enhancing nongenomic neuroprotection have been described. This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives.

AB - Nongenomic estrogen signaling pathways involve extranuclear estrogen receptors or function independently from estrogen receptors. These pathways participate in neuroprotection elicited by the hormone. Additional nongenomic neuroprotective effects are attributable to antioxidant and antiinflammatory actions of estrogens. Numerous chemical modifications to afford neuroprotective compounds from estrogens while eliminating estrogenicity and maintaining or enhancing nongenomic neuroprotection have been described. This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives.

KW - Antioxidant

KW - Estrogen

KW - Neuroprotection

KW - Nongenomic mechanism

UR - http://www.scopus.com/inward/record.url?scp=33947694215&partnerID=8YFLogxK

U2 - 10.1016/j.pharmthera.2007.01.006

DO - 10.1016/j.pharmthera.2007.01.006

M3 - Review article

C2 - 17336390

AN - SCOPUS:33947694215

SN - 0163-7258

VL - 114

SP - 1

EP - 12

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 1

ER -

Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this