Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum β-lactamase inhibitors: Crystallographic structures show unexpected binding of 1,4-thiazepine intermediates

Aranapakam M. Venkatesan, Yansong Gu, Osvaldo Dos Santos, Takao Abe, Atul Agarwal, Youjun Yang, Peter J. Petersen, William J. Weiss, Tarek S. Mansour, Michiyoshi Nukaga, Andrea M. Hujer, Robert A. Bonomo, James R. Knox

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Medicine & Life Sciences