Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: Evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods

Aranapakam M. Venkatesan, Atul Agarwal, Takao Abe, Hideki Ushirogochi, Itsuka Yamamura, Mihira Ado, Takasaki Tsuyoshi, Osvaldo Dos Santos, Yansong Gu, Fuk Wah Sum, Zhong Li, Gerry Francisco, Yang I. Lin, Peter J. Petersen, Youjun Yang, Toshio Kumagai, William J. Weiss, David M. Shlaes, James R. Knox, Tarek S. Mansour