Structural markers in prostate cancer serum imaged ex vivo using cryogenic transmission electron microscopy

Nazneen Aziz, Ashish K. Jha, Chris Thanos, Riyaz Basha, Arijit Bose

Research output: Contribution to journalArticle

Abstract

We used cryogenic transmission electron microscopy (cryo-TEM) to identify differences in macromolecular structures present in the serum from healthy individuals (HI) and prostate cancer (PCa) patients and show that these differences are potential markers for disease. Using a murine orthotopic model of human PCa, we determined that some of these structural markers in serum are associated with the tumour burden. These findings signify the potential of this nanoscale ex vivo imaging technology of body fluids as a platform for discovering early markers of PCa and other diseases.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalJournal of Electron Microscopy
Volume59
Issue number5
DOIs
StatePublished - 1 Oct 2010

Keywords

  • biomarkers
  • imaging
  • nanopathology
  • prostate cancer
  • secreted macromolecules
  • serum

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