Structural determinants of affinity enhancement between GoLoco motifs and G-protein α subunit mutants

Medicine & Life Sciences

• Protein Subunits 100%
• GTP-Binding Proteins 87%
• Peptides 55%
• Gi-Go GTP-Binding Protein alpha Subunits 33%
• Asymmetric Cell Division 32%
• Calorimetry 30%
• Fluorescence Polarization 29%
• Gain of Function Mutation 28%
• Amino Acid Motifs 28%
• Entropy 26%
• Leucine 22%
• Point Mutation 21%
• Epithelium 16%
• Proteins 16%
• Mutation 12%

Chemical Compounds

• Mutation 55%
• Peptide 50%
• GDP 27%
• Isothermal Titration Calorimetry 24%
• Hydrophobic Surface 23%
• Monte Carlo Method 23%
• Leucine 22%
• Disorder 18%
• Sampling 18%
• Entropy 17%
• Flexibility 17%
• Enthalpy 17%
• Kd 16%
• Polarization 16%
• Dissociation 15%
• Fluorescence 12%
• Crystal Structure 10%
• Protein 9%