Store-operated calcium entry and diabetic complications

Sarika Chaudhari, Rong Ma

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Store-operated Ca2+ entry (SOCE) is mediated by the store-operated Ca2+ channel (SOC) that opens upon depletion of internal Ca2+ stores following activation of G protein-coupled receptors or receptor tyrosine kinases. Over the past two decades, the physiological and pathological relevance of SOCE has been extensively studied. Recently, accumulating evidence suggests associations of altered SOCE with diabetic complications. This review focuses on the implication of SOCE as it pertains to various complications resulting from diabetes. We summarize recent findings by us and others on the involvement of abnormal SOCE in the development of diabetic complications, such as diabetic nephropathy and diabetic vasculopathy. The underlying mechanisms that mediate the diabetes-associated alterations of SOCE are also discussed. The SOCE pathway may be considered as a potential therapeutic target for diabetes-associated diseases.

Original languageEnglish
Pages (from-to)343-352
Number of pages10
JournalExperimental Biology and Medicine
Volume241
Issue number4
DOIs
StatePublished - 1 Feb 2016

Keywords

  • Store-operated Ca channel
  • calcium
  • diabetes
  • diabetic complications
  • store-operated Ca entry

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