Abstract
WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone 1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon3-7.
| Original language | English |
|---|---|
| Pages (from-to) | 722-723 |
| Number of pages | 2 |
| Journal | Nature |
| Volume | 261 |
| Issue number | 5562 |
| DOIs | |
| State | Published - 1 Dec 1976 |
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Stimulation of active Na transport by phospholipase C. / Yorio, Thomas; Bentley, P. J.
In: Nature, Vol. 261, No. 5562, 01.12.1976, p. 722-723.Research output: Contribution to journal › Article
TY - JOUR
T1 - Stimulation of active Na transport by phospholipase C
AU - Yorio, Thomas
AU - Bentley, P. J.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone 1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon3-7.
AB - WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone 1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon3-7.
UR - http://www.scopus.com/inward/record.url?scp=0017063526&partnerID=8YFLogxK
U2 - 10.1038/261722a0
DO - 10.1038/261722a0
M3 - Article
C2 - 1084482
AN - SCOPUS:0017063526
VL - 261
SP - 722
EP - 723
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5562
ER -