Stimulation of active Na transport by phospholipase C

Thomas Yorio, P. J. Bentley

Research output: Contribution to journalArticle

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Abstract

WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone 1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon3-7.

Original languageEnglish
Pages (from-to)722-723
Number of pages2
JournalNature
Volume261
Issue number5562
DOIs
Publication statusPublished - 1 Dec 1976

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