Stimulation of active Na transport by phospholipase C

Thomas Yorio; P. J. Bentley

doi:10.1038/261722a0

Stimulation of active Na transport by phospholipase C

Thomas Yorio, P. J. Bentley

Research output: Contribution to journal › Article › peer-review

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Abstract

WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone ^1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon^3-7.

Original language	English
Pages (from-to)	722-723
Number of pages	2
Journal	Nature
Volume	261
Issue number	5562
DOIs	https://doi.org/10.1038/261722a0
State	Published - 1 Dec 1976

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abstract = "WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone 1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon3-7.",

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AB - WE have found that an enzyme, phospolipase C, which has a very specific action in cleaving phosphatidylcholine (lecithin) at its ester linkage (between the α carbon of glycerol and the phosphoryl group of phosphorylcholine) stimulates active Na transport across frog skin in vitro. This action may provide both insight into the sort of processes involved in transepithelial Na transport and a model for the action of proteins induced by aldosterone 1,2. This hormone stimulates Na transport across epithelial membranes which, apart from the kidney tubules, include in vitro frog skin, and toad urinary bladder and colon3-7.

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