Steroid-induced ocular hypertension and effects of glucocorticoids on the trabecular meshwork

A. Sethi, A. F. Clark

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The therapeutic use of glucocorticoids can cause steroid-induced ocular hypertension and that can lead to secondary glaucoma in susceptible individuals. This elevated intraocular pressure is due to increased aqueous outflow resistance and is associated with morphological and biochemical changes to the trabecular meshwork, and many of these changes mimic what occurs in primary open-angle glaucoma. Glucocorticoids have a wide variety of effects on the trabecular meshwork (TM), altering extracellular matrix metabolism, the cytoskeleton, gene and protein expression as well as inhibiting TM cell functions. Despite years of research on the effects of glucocorticoids on the TM, we still do not know the molecular mechanisms responsible for steroid-induced ocular hypertension.

Original languageEnglish
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages219-223
Number of pages5
ISBN (Electronic)9780128093245
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Glaucoma
  • Glucocorticoids
  • Steroids
  • Trabecular meshwork

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