Statistical power of an exact test of hardy-weinberg proportions of genotypic data at a multiallelic locus

Ranajit Chakraborty, Yixi Zhong

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A computer algorithm for numerical evaluation of the statistical power of an exact test of Hardy-Weinberg genotypic proportions (HWP), developed here, indicates that the power is dependent on the number of segregating alleles as well as allele frequencies. While low levels of departure from the null hypothesis are difficult to detect from single-locus data, should such deviation be due to population substructuring, multiple loci, at each of which the number of segregating alleles is large (as seen with hypervariable loci), may easily detect even low levels of departure from HWP. Undetected small levels of departure may still provide conservative estimates of genotype frequencies from allele frequency data, following the current practice in forensic genctics.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalHuman Heredity
Volume44
Issue number1
DOIs
StatePublished - 1 Jan 1994

Keywords

  • Monte carlo
  • Multiple alleles
  • Permutation test
  • Random mating
  • Type II error

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