Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections

Marian Lumanug Gaviola, Emily C. Scribe, Haley N. Leverett, Meredith Howard

Research output: Contribution to journalReview article

Abstract

Purpose: To review the effects of statin use in patients at risk for or diagnosed with Clostridium difficile infection (CDI) on CDI incidence, treatment success, and mortality. Methods: A literature search was performed through January 2019 using the following terms: statins, HMG-CoA inhibitors, Clostridium difficile, Clostridium difficile associated diarrhea, and Clostridium difficile infection. Additional references were identified from a review of literature citations. Studies evaluating statin effects on C difficile-related outcomes were included. Results: A total of 8 studies were identified for inclusion in this review. All studies were retrospective. Five studies reported the association between statin use and the development of CDI, suggesting that statins may decrease risk of CDI development in patients already on statin. In one study, there was an improved treatment response against CDI with the use of statin. Three retrospective studies evaluated statin use and mortality from CDI and only one study found significant mortality benefit in statin users. Conclusions: Statin use may have a protective effect against the development of CDI and improve CDI treatment success; however, it is unclear if use confers a mortality benefit. Current data remain sparse and larger, prospective studies are needed to confirm current results and identify the specific population that may benefit the most from this intervention.

Original languageEnglish
JournalJournal of Pharmacy Practice
DOIs
StatePublished - 1 Jan 2019

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Clostridium Infections
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Clostridium difficile
Mortality
Incidence
Therapeutics
Retrospective Studies
Diarrhea

Keywords

  • Clostridium difficile
  • HMG-CoA inhibitors
  • infectious diarrhea
  • infectious disease
  • statins

Cite this

@article{225453dc289f4fdc90159468fc4c43d8,
title = "Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections",
abstract = "Purpose: To review the effects of statin use in patients at risk for or diagnosed with Clostridium difficile infection (CDI) on CDI incidence, treatment success, and mortality. Methods: A literature search was performed through January 2019 using the following terms: statins, HMG-CoA inhibitors, Clostridium difficile, Clostridium difficile associated diarrhea, and Clostridium difficile infection. Additional references were identified from a review of literature citations. Studies evaluating statin effects on C difficile-related outcomes were included. Results: A total of 8 studies were identified for inclusion in this review. All studies were retrospective. Five studies reported the association between statin use and the development of CDI, suggesting that statins may decrease risk of CDI development in patients already on statin. In one study, there was an improved treatment response against CDI with the use of statin. Three retrospective studies evaluated statin use and mortality from CDI and only one study found significant mortality benefit in statin users. Conclusions: Statin use may have a protective effect against the development of CDI and improve CDI treatment success; however, it is unclear if use confers a mortality benefit. Current data remain sparse and larger, prospective studies are needed to confirm current results and identify the specific population that may benefit the most from this intervention.",
keywords = "Clostridium difficile, HMG-CoA inhibitors, infectious diarrhea, infectious disease, statins",
author = "Gaviola, {Marian Lumanug} and Scribe, {Emily C.} and Leverett, {Haley N.} and Meredith Howard",
year = "2019",
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language = "English",
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}

Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections. / Gaviola, Marian Lumanug; Scribe, Emily C.; Leverett, Haley N.; Howard, Meredith.

In: Journal of Pharmacy Practice, 01.01.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections

AU - Gaviola, Marian Lumanug

AU - Scribe, Emily C.

AU - Leverett, Haley N.

AU - Howard, Meredith

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To review the effects of statin use in patients at risk for or diagnosed with Clostridium difficile infection (CDI) on CDI incidence, treatment success, and mortality. Methods: A literature search was performed through January 2019 using the following terms: statins, HMG-CoA inhibitors, Clostridium difficile, Clostridium difficile associated diarrhea, and Clostridium difficile infection. Additional references were identified from a review of literature citations. Studies evaluating statin effects on C difficile-related outcomes were included. Results: A total of 8 studies were identified for inclusion in this review. All studies were retrospective. Five studies reported the association between statin use and the development of CDI, suggesting that statins may decrease risk of CDI development in patients already on statin. In one study, there was an improved treatment response against CDI with the use of statin. Three retrospective studies evaluated statin use and mortality from CDI and only one study found significant mortality benefit in statin users. Conclusions: Statin use may have a protective effect against the development of CDI and improve CDI treatment success; however, it is unclear if use confers a mortality benefit. Current data remain sparse and larger, prospective studies are needed to confirm current results and identify the specific population that may benefit the most from this intervention.

AB - Purpose: To review the effects of statin use in patients at risk for or diagnosed with Clostridium difficile infection (CDI) on CDI incidence, treatment success, and mortality. Methods: A literature search was performed through January 2019 using the following terms: statins, HMG-CoA inhibitors, Clostridium difficile, Clostridium difficile associated diarrhea, and Clostridium difficile infection. Additional references were identified from a review of literature citations. Studies evaluating statin effects on C difficile-related outcomes were included. Results: A total of 8 studies were identified for inclusion in this review. All studies were retrospective. Five studies reported the association between statin use and the development of CDI, suggesting that statins may decrease risk of CDI development in patients already on statin. In one study, there was an improved treatment response against CDI with the use of statin. Three retrospective studies evaluated statin use and mortality from CDI and only one study found significant mortality benefit in statin users. Conclusions: Statin use may have a protective effect against the development of CDI and improve CDI treatment success; however, it is unclear if use confers a mortality benefit. Current data remain sparse and larger, prospective studies are needed to confirm current results and identify the specific population that may benefit the most from this intervention.

KW - Clostridium difficile

KW - HMG-CoA inhibitors

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