Spectroscopic properties of curcumin: Orientation of transition moments

Anindita Mukerjee, Thomas J. Sørensen, Amalendu Prakash Ranjan, Sangram Limbaji Raut, Ignacy Gryczynski, Jamboor K. Vishwanatha, Zygmunt Gryczynski

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Curcumin, a naturally occurring yellow-orange pigment with potent antioxidant and antitumor properties, has been attracting researchers from a wide range of fields including chemistry, spectroscopy, biology, and medicine. Ultrafast excited-state processes such as solvation and excited-state intramolecular hydrogen atom transfer (ESIHT) make curcumin an attractive agent for photodynamic therapy. In this report we present studies of linear dichroism and fluorescence anisotropy in oriented and isotropic media. The results show transition moments (long wavelength absorption and emission) oriented along the long molecular axis. Comparison of linear dichroism and excitation anisotropy in oriented and isotropic media suggests that excited-state intramolecular hydrogen atom transfer is probably associated with intramolecular conformational changes that can be constrained in highly stretched poly(vinyl alcohol) (PVA) film.

Original languageEnglish
Pages (from-to)12679-12684
Number of pages6
JournalJournal of Physical Chemistry B
Volume114
Issue number39
DOIs
StatePublished - 7 Oct 2010

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