Some sampling properties of selectively neutral alleles:Effects of variability of mutation rates

Ranajit Chakraborty; Paul A. Fuerst

doi:10.1017/S0016672300019492

Some sampling properties of selectively neutral alleles:Effects of variability of mutation rates

Ranajit Chakraborty, Paul A. Fuerst

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Some sampling properties related with the mean and variance of the number of alleles and single locus heterozygosity are derived to study the effect of variations in mutation rate of selectively neutral alleles. The correlation between single locus heterozygosity and the number of alleles is also derived. Monte Carlo simulation is conducted to examine the effect of stepwise mutations. The relevance of these results in estimating the population parameter, 4N_eν, is discussed in connexion with neutralist-selectionist controversy over the maintenance of genetic variability in natural populations.

Original language	English
Pages (from-to)	253-267
Number of pages	15
Journal	Genetical Research
Volume	34
Issue number	3
DOIs	https://doi.org/10.1017/S0016672300019492
State	Published - Dec 1979

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abstract = "Some sampling properties related with the mean and variance of the number of alleles and single locus heterozygosity are derived to study the effect of variations in mutation rate of selectively neutral alleles. The correlation between single locus heterozygosity and the number of alleles is also derived. Monte Carlo simulation is conducted to examine the effect of stepwise mutations. The relevance of these results in estimating the population parameter, 4Neν, is discussed in connexion with neutralist-selectionist controversy over the maintenance of genetic variability in natural populations.",

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AB - Some sampling properties related with the mean and variance of the number of alleles and single locus heterozygosity are derived to study the effect of variations in mutation rate of selectively neutral alleles. The correlation between single locus heterozygosity and the number of alleles is also derived. Monte Carlo simulation is conducted to examine the effect of stepwise mutations. The relevance of these results in estimating the population parameter, 4Neν, is discussed in connexion with neutralist-selectionist controversy over the maintenance of genetic variability in natural populations.

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Some sampling properties of selectively neutral alleles:Effects of variability of mutation rates

Abstract

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