Some sampling properties of selectively neutral alleles:Effects of variability of mutation rates

Ranajit Chakraborty, Paul A. Fuerst

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Some sampling properties related with the mean and variance of the number of alleles and single locus heterozygosity are derived to study the effect of variations in mutation rate of selectively neutral alleles. The correlation between single locus heterozygosity and the number of alleles is also derived. Monte Carlo simulation is conducted to examine the effect of stepwise mutations. The relevance of these results in estimating the population parameter, 4Neν, is discussed in connexion with neutralist-selectionist controversy over the maintenance of genetic variability in natural populations.

Original languageEnglish
Pages (from-to)253-267
Number of pages15
JournalGenetical Research
Issue number3
Publication statusPublished - 1 Jan 1979


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