Solvatochromic dye LDS 798 as microviscosity and pH probe

Hung Doan, Marlius Castillo, Micheline Bejjani, Zhangatay Nurekeyev, Sergei V. Dzyuba, Ignacy Gryczynski, Zygmunt Gryczynski, Sangram Raut

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Styryl dyes, specifically LDS group dyes, are known solvatochromic and electrochromic probes for monitoring mitochondrial potential in cellular environments. However, the ability of these dyes to respond to fluctuations in viscosity, pH and temperature has not been established. In this study, we demonstrated that LDS 798 (also known as Styryl-11) can sense environmental viscosity (via fluorescence lifetime changes) as well as pH changes (ratiometric intensity change) in the absence of polarity variations. Polarity changes can be probed by spectral changes using LDS 798. Therefore, all properties of the media should be considered, when these types of dyes are used as electrochromic/solvatochromic sensors in cellular environments.

Original languageEnglish
Pages (from-to)29934-29939
Number of pages6
JournalPhysical Chemistry Chemical Physics
Volume19
Issue number44
DOIs
StatePublished - 2017

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