SNP typing strategies

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Abstract

Single nucleotide polymorphism (SNP) typing is likely to be an adjunct forensic technology to be used when short tandem repeat (STR) typing fails to yield a result or when only a partial profile is obtained. It is anticipated that forensic SNP analyses will be applied to typing mtDNA, Y chromosome lineage analyses, characterizing highly degraded DNA samples, ssessing biogeographical ancestry, and typing for determining physical characteristics. As examples, three SNP typing strategies briefly described. They are SNaP shot™, SNPstream® Ultra High Throughput System, and electrospray ionization mass spectrometry. The latter approach offers certain advantages for SNP analysis, particularly so for mtDNA typing.

Original languageEnglish
Pages (from-to)S139-S142
JournalForensic Science International
Volume146
Issue numberSUPPL.
DOIs
StatePublished - 2 Dec 2004

Keywords

  • DNA typing
  • Electrospray ionization mass spectrometry
  • Forensic science
  • Primer extension
  • SNPstream®
  • SNaP shot™
  • Single nucleotide polymorphism (SNP)
  • Ultra High Throughput System

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