TY - JOUR
T1 - Six months of unsupervised exercise training lowers blood pressure during moderate, but not vigorous, aerobic exercise in adults with well-healed burn injuries
AU - Watso, Joseph C.
AU - Romero, Steven A.
AU - Moralez, Gilbert
AU - Huang, Mu
AU - Cramer, Matthew N.
AU - Johnson, Elias
AU - Crandall, Craig G.
N1 - Funding Information:
We thank the individuals who participated in this research. We also thank Manall Jaffery, Jan Karel Petric, Naomi Kennedy, Amy Adams, Sarah Bailey, and Zaid Mohammed for assistance with the study. This research was supported by the National Institutes of Health (NIH) Grant R01GM068865 (to C. G. Crandall), US Department of Defense W81XWH-15-1-0647 (to. C. G. Crandall), NIH K01HL160772 (to J. C. Watso), NIH F32HL154559 (to J. C. Watso), NIH F32GM117693 (to S. A. Romero), and NIH Administrative Supplements to Promote Diversity in Health-Related Research (to S. A. Romero and G. Moralez).
Funding Information:
This research was supported by the National Institutes of Health (NIH) Grant R01GM068865 (to C. G. Crandall), US Department of Defense W81XWH-15-1-0647 (to. C. G. Crandall), NIH K01HL160772 (to J. C. Watso), NIH F32HL154559 (to J. C. Watso), NIH F32GM117693 (to S. A. Romero), and NIH Administrative Supplements to Promote Diversity in Health-Related Research (to S. A. Romero and G. Moralez).
Publisher Copyright:
Copyright © 2022 the American Physiological Society.
PY - 2022/9
Y1 - 2022/9
N2 - Exercise training reduces cardiovascular disease risk, partly due to arterial blood pressure (BP) lowering at rest and during fixed-load exercise. However, it is unclear whether exercise training can reduce BP at rest and during exercise in adults with well-healed burn injuries. Therefore, the purpose of this investigation was to test the hypothesis that 6 mo of unsupervised exercise training reduces BP at rest and during lower-body cycle ergometry in adults with well-healed burn injuries. Thirty-nine adults (28 with well-healed burn injuries and 11 controls) completed 6 mo of unsupervised, progressive exercise training including endurance, resistance, and high-intensity interval components. Before and after exercise training, we measured BP at rest, during fixed-load submaximal exercise (50 and 75 W), during fixed-intensity submaximal exercise (40% and 70% of V̇O2peak), and during maximal exercise on a lower-body cycle ergometer. We compared cardiovascular variables using two-way ANOVA (group × pre/ postexercise training [repeated factor]). Adults with well-healed burn injuries had higher diastolic BP at rest (P = 0.04), which was unchanged by exercise training (P = 0.26). Exercise training reduced systolic, mean, and diastolic BP during fixed-load cycling exercise at 75 W in adults with well-healed burn injuries (P ≤ 0.03 for all), but not controls (P ≥ 0.67 for all). Exercise training also reduced mean and diastolic BP during exercise at 40% (P ≤ 0.02 for both), but not at 70% (P ≥ 0.18 for both), of V_ O2peak. These data suggest that a 6-mo unsupervised exercise training program lowers BP during moderate, but not vigorous, aerobic exercise in adults with well-healed burn injuries.
AB - Exercise training reduces cardiovascular disease risk, partly due to arterial blood pressure (BP) lowering at rest and during fixed-load exercise. However, it is unclear whether exercise training can reduce BP at rest and during exercise in adults with well-healed burn injuries. Therefore, the purpose of this investigation was to test the hypothesis that 6 mo of unsupervised exercise training reduces BP at rest and during lower-body cycle ergometry in adults with well-healed burn injuries. Thirty-nine adults (28 with well-healed burn injuries and 11 controls) completed 6 mo of unsupervised, progressive exercise training including endurance, resistance, and high-intensity interval components. Before and after exercise training, we measured BP at rest, during fixed-load submaximal exercise (50 and 75 W), during fixed-intensity submaximal exercise (40% and 70% of V̇O2peak), and during maximal exercise on a lower-body cycle ergometer. We compared cardiovascular variables using two-way ANOVA (group × pre/ postexercise training [repeated factor]). Adults with well-healed burn injuries had higher diastolic BP at rest (P = 0.04), which was unchanged by exercise training (P = 0.26). Exercise training reduced systolic, mean, and diastolic BP during fixed-load cycling exercise at 75 W in adults with well-healed burn injuries (P ≤ 0.03 for all), but not controls (P ≥ 0.67 for all). Exercise training also reduced mean and diastolic BP during exercise at 40% (P ≤ 0.02 for both), but not at 70% (P ≥ 0.18 for both), of V_ O2peak. These data suggest that a 6-mo unsupervised exercise training program lowers BP during moderate, but not vigorous, aerobic exercise in adults with well-healed burn injuries.
KW - cardiac output
KW - cardioprotection
KW - exercise hypertension
KW - heart rate
KW - rate pressure product
UR - http://www.scopus.com/inward/record.url?scp=85138443216&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00181.2022
DO - 10.1152/japplphysiol.00181.2022
M3 - Article
C2 - 35952345
AN - SCOPUS:85138443216
SN - 8750-7587
VL - 133
SP - 742
EP - 754
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 3
ER -