Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis

Phillip R. Purnell, Benjamin L. Addicks, Habib G. Zalzal, Scott Shapiro, Sijin Wen, Hassan H. Ramadan, Vincent Setola, David P. Siderovski

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with altered innate immune responses to multiple bacterially derived signals. Objective: To determine in CRS the frequency of six SNPs in genes with known bitter tastant signaling function. Methods: Genomic DNA was isolated from 74 CRS volunteers in West Virginia, and allele frequency was determined and compared with demographically matched data from the 1,000 Genomes database. Results: For two SNPs in a gene recently associated with bitterant signaling regulation, RGS21, there were no associations with CRS (although the frequency of the minor allele of RGS21, rs7528947, was seen to increase with increasing Lund-Mackay CT staging score). Two TAS2R bitter taste receptor gene variants (TAS2R19 rs10772420 and TAS2R38 rs713598), identified in prior CRS genetics studies, were found to have similar associations in this study. Conclusion: Unique to our study is the establishment of an association between CRS in this patient population and GNB3 SNP rs5443, a variation in an established G protein component downstream of bitterant receptor signal transduction.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume180
Issue number1
DOIs
StatePublished - 1 Aug 2019

Keywords

  • Bitterant signaling
  • Chronic rhinosinusitis
  • Genetics
  • Innate immune response
  • Single nucleotide polymorphism

Fingerprint Dive into the research topics of 'Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis'. Together they form a unique fingerprint.

  • Cite this