Simulation results with stepwise mutation model and their interpretations

Ranajit Chakraborty

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.

Original languageEnglish
Pages (from-to)313-322
Number of pages10
JournalJournal of Molecular Evolution
Volume9
Issue number4
DOIs
StatePublished - 1 Dec 1977

Fingerprint

mutation
Mutation
Alleles
Population
simulation
allele
Mutation Rate
Population Density
alleles
Codon
Theoretical Models
codons
heterozygosity
genetic variation
population size
prediction

Keywords

  • Electrophoresis
  • Heterozygosity
  • No. of alleles
  • Protein polymorphism
  • Simulation

Cite this

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Simulation results with stepwise mutation model and their interpretations. / Chakraborty, Ranajit.

In: Journal of Molecular Evolution, Vol. 9, No. 4, 01.12.1977, p. 313-322.

Research output: Contribution to journalArticleResearchpeer-review

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PY - 1977/12/1

Y1 - 1977/12/1

N2 - Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.

AB - Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.

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KW - No. of alleles

KW - Protein polymorphism

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