Simulation results with stepwise mutation model and their interpretations

Ranajit Chakraborty

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Abstract

Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.

Original languageEnglish
Pages (from-to)313-322
Number of pages10
JournalJournal of Molecular Evolution
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Dec 1977

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Keywords

  • Electrophoresis
  • Heterozygosity
  • No. of alleles
  • Protein polymorphism
  • Simulation

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