Abstract
Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 313-322 |
| Number of pages | 10 |
| Journal | Journal of Molecular Evolution |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Dec 1977 |
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Keywords
- Electrophoresis
- Heterozygosity
- No. of alleles
- Protein polymorphism
- Simulation
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Simulation results with stepwise mutation model and their interpretations. / Chakraborty, Ranajit.
In: Journal of Molecular Evolution, Vol. 9, No. 4, 01.12.1977, p. 313-322.Research output: Contribution to journal › Article
TY - JOUR
T1 - Simulation results with stepwise mutation model and their interpretations
AU - Chakraborty, Ranajit
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.
AB - Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older alleles (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.
KW - Electrophoresis
KW - Heterozygosity
KW - No. of alleles
KW - Protein polymorphism
KW - Simulation
UR - http://www.scopus.com/inward/record.url?scp=0017683450&partnerID=8YFLogxK
U2 - 10.1007/BF01796093
DO - 10.1007/BF01796093
M3 - Article
C2 - 894733
AN - SCOPUS:0017683450
VL - 9
SP - 313
EP - 322
JO - Journal of Molecular Evolution
JF - Journal of Molecular Evolution
SN - 0022-2844
IS - 4
ER -