Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging

Kyung Min Lee, Arup Neogi, Purnima Basu Neogi, Minjung Kim, Bongsoo Kim, Rafal Luchowski, Zygmunt Gryczynski, Nils Calander, Tae Youl Choif

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We present herein a silver nanostructure-assisted sensing platform which consists of a combined structure of Ag nanowire (NW) and nanodot (ND) array. Highly enhanced fluorescence from fluorophore is attributed to a strongly coupled optical near-field interaction between proximately located Ag NW and NDs. We obtained enhanced fluorescence intensity with up to 140 folds, as contrasted from background intensity, reaching a theoretical maximum value. On the other hand, fluorescence lifetime was greatly reduced to 0.27 ns (from 2.17 ns for the same fluorophores without nanostructure). This novel platform can be a promising utility for optical imaging and labeling of biological systems with a great sensitivity.

Original languageEnglish
Article number056008
JournalJournal of Biomedical Optics
Volume16
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Ag nanowire
  • Cell imaging
  • Fluorescence
  • Focused ion beam
  • Nanodot

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    Lee, K. M., Neogi, A., Neogi, P. B., Kim, M., Kim, B., Luchowski, R., Gryczynski, Z., Calander, N., & Choif, T. Y. (2011). Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging. Journal of Biomedical Optics, 16(5), [056008]. https://doi.org/10.1117/1.3579157