Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway

Keyphrases

• Signaling Pathway 100%
• Anticancer Activity 100%
• Peptide-based 100%
• Conserved Regions 100%
• Cancer Cell Migration 100%
• Short Peptides 100%
• Breast Cancer Cells 50%
• Overexpression 50%
• Protein Expression 50%
• Cancer Progression 50%
• Tumor Growth 50%
• Pharmacokinetic Properties 50%
• Nuclear Translocation 50%
• Epidermal Growth Factor 50%
• Orthotopic Model 50%
• IC50 50%
• Signal Transduction Pathway 50%
• MDA-MB-231 Cells 50%
• Cancer Pathways 50%
• Migration Invasion 50%
• Leucine 50%
• Nuclear factor-κB 50%
• Immunoreceptor Tyrosine-based Activation Motif 50%
• Prenylation 50%
• Mouse Plasma 50%
• Metastatic Breast Cancer 50%
• Expression Change 50%
• Peptide Complexes 50%
• Cancer Invasion 50%
• In Vivo Pharmacokinetics 50%
• Molecular Docking 50%
• Anticancer Peptides 50%
• Bioactive Peptides 50%
• Breast Cancer Cell Migration 50%
• D-isomer 50%
• Protein Sequence 50%
• CD Spectra 50%
• Migration Inhibition 50%
• Epithelial-mesenchymal Transition Pathway 50%
• Orthotopic Breast Cancer Model 50%
• Peptide Targeting 50%
• Transcriptomic Expression 50%

Biochemistry, Genetics and Molecular Biology

• Signal Transduction 100%
• Enhancer Region 100%
• Antineoplastic Activity 100%
• Cancer Cell 57%
• Cell Migration 42%
• Mouse Model 14%
• Protein Expression 14%
• Tumor Progression 14%
• Pharmacokinetics 14%
• Peptide Sequence 14%
• Anticancer 14%
• Low Drug Dose 14%
• IC50 14%
• Transcriptomics 14%
• Mesenchymal-Epithelial Transition 14%
• Immunoreceptor Tyrosine-Based Activation Motif 14%
• Prenylation 14%
• Cell Invasion 14%
• Epidermal Growth Factor 14%
• Immunoglobulin Enhancer Binding Protein 14%
• Pharmacokinetic Properties 14%
• Migration Inhibition 14%
• Docking (Molecular) 14%
• Blood Plasma 14%
• Isoleucine 14%