Sexual behaviors and other risk factors for oral human papillomavirus infections in young women

Robert L. Cook, Erika L. Thompson, Natalie E. Kelso, John Friary, Jennifer Hosford, Phillip Barkley, Virginia J. Dodd, Martha Abrahamsen, Shaun Ajinkya, Peter Daniel Obesso, Mohammed H. Rashid, Anna R. Giuliano

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

BACKGROUND: Oral human papillomavirus (HPV) is associated with a rising incidence of certain head and neck cancers, and oral sex has been associated with oral HPV. This study sought to identify more specific patterns of oral sexual activity, including self-inoculation, that are associated with oral HPV infections in young women. METHODS: A total of 1010 women attending a large university completed a computer-based questionnaire and provided oral specimens that were tested for any oral HPV using a Linear Array assay that detects any HPV as well as 37 HPV genotypes. Twenty-seven women provided additional samples up to 12 months after enrollment. Bivariable and multivariable analyses were conducted to identify oral sexual patterns and other risk factors associated with prevalent oral HPV. RESULTS: Nineteen women had prevalent oral HPV (1.9%), with 10 women (1%) having a type-specific infection. Oral HPV was significantly associated with lifetime coital sex partnership numbers (P = 0.03), lifetime and yearly oral sex partnership numbers (P < 0.01), and hand and/or sex toy transfer from genitals to mouth (P < 0.001). Oral HPV was also associated with greater use of alcohol, cigarettes, marijuana, and sharing of smoking devices, lipstick, or toothbrushes (P < 0.05 for each), with an apparent dose-response for alcohol use and smoking behavior, stratified by number of sexual partners. Of 7 women with prevalent HPV who provided follow-up samples, none had evidence of a persistent type-specific infection. CONCLUSIONS: These data provide additional evidence of transmission of oral HPV from oral sexual activity and also suggest possible transmission from self-inoculation or sharing of oral products.

Original languageEnglish
Pages (from-to)486-492
Number of pages7
JournalSexually Transmitted Diseases
Volume41
Issue number8
DOIs
StatePublished - Aug 2014

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Papillomavirus Infections
Sexual Behavior
Marijuana Smoking
Alcohols
Play and Playthings
Sexual Partners
Mouth Neoplasms
Head and Neck Neoplasms
Infection
Tobacco Products
Mouth
Hand
Smoking
Genotype

Cite this

Cook, Robert L. ; Thompson, Erika L. ; Kelso, Natalie E. ; Friary, John ; Hosford, Jennifer ; Barkley, Phillip ; Dodd, Virginia J. ; Abrahamsen, Martha ; Ajinkya, Shaun ; Obesso, Peter Daniel ; Rashid, Mohammed H. ; Giuliano, Anna R. / Sexual behaviors and other risk factors for oral human papillomavirus infections in young women. In: Sexually Transmitted Diseases. 2014 ; Vol. 41, No. 8. pp. 486-492.
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title = "Sexual behaviors and other risk factors for oral human papillomavirus infections in young women",
abstract = "BACKGROUND: Oral human papillomavirus (HPV) is associated with a rising incidence of certain head and neck cancers, and oral sex has been associated with oral HPV. This study sought to identify more specific patterns of oral sexual activity, including self-inoculation, that are associated with oral HPV infections in young women. METHODS: A total of 1010 women attending a large university completed a computer-based questionnaire and provided oral specimens that were tested for any oral HPV using a Linear Array assay that detects any HPV as well as 37 HPV genotypes. Twenty-seven women provided additional samples up to 12 months after enrollment. Bivariable and multivariable analyses were conducted to identify oral sexual patterns and other risk factors associated with prevalent oral HPV. RESULTS: Nineteen women had prevalent oral HPV (1.9{\%}), with 10 women (1{\%}) having a type-specific infection. Oral HPV was significantly associated with lifetime coital sex partnership numbers (P = 0.03), lifetime and yearly oral sex partnership numbers (P < 0.01), and hand and/or sex toy transfer from genitals to mouth (P < 0.001). Oral HPV was also associated with greater use of alcohol, cigarettes, marijuana, and sharing of smoking devices, lipstick, or toothbrushes (P < 0.05 for each), with an apparent dose-response for alcohol use and smoking behavior, stratified by number of sexual partners. Of 7 women with prevalent HPV who provided follow-up samples, none had evidence of a persistent type-specific infection. CONCLUSIONS: These data provide additional evidence of transmission of oral HPV from oral sexual activity and also suggest possible transmission from self-inoculation or sharing of oral products.",
author = "Cook, {Robert L.} and Thompson, {Erika L.} and Kelso, {Natalie E.} and John Friary and Jennifer Hosford and Phillip Barkley and Dodd, {Virginia J.} and Martha Abrahamsen and Shaun Ajinkya and Obesso, {Peter Daniel} and Rashid, {Mohammed H.} and Giuliano, {Anna R.}",
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Cook, RL, Thompson, EL, Kelso, NE, Friary, J, Hosford, J, Barkley, P, Dodd, VJ, Abrahamsen, M, Ajinkya, S, Obesso, PD, Rashid, MH & Giuliano, AR 2014, 'Sexual behaviors and other risk factors for oral human papillomavirus infections in young women', Sexually Transmitted Diseases, vol. 41, no. 8, pp. 486-492. https://doi.org/10.1097/OLQ.0000000000000159

Sexual behaviors and other risk factors for oral human papillomavirus infections in young women. / Cook, Robert L.; Thompson, Erika L.; Kelso, Natalie E.; Friary, John; Hosford, Jennifer; Barkley, Phillip; Dodd, Virginia J.; Abrahamsen, Martha; Ajinkya, Shaun; Obesso, Peter Daniel; Rashid, Mohammed H.; Giuliano, Anna R.

In: Sexually Transmitted Diseases, Vol. 41, No. 8, 08.2014, p. 486-492.

Research output: Contribution to journalArticle

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AU - Cook, Robert L.

AU - Thompson, Erika L.

AU - Kelso, Natalie E.

AU - Friary, John

AU - Hosford, Jennifer

AU - Barkley, Phillip

AU - Dodd, Virginia J.

AU - Abrahamsen, Martha

AU - Ajinkya, Shaun

AU - Obesso, Peter Daniel

AU - Rashid, Mohammed H.

AU - Giuliano, Anna R.

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N2 - BACKGROUND: Oral human papillomavirus (HPV) is associated with a rising incidence of certain head and neck cancers, and oral sex has been associated with oral HPV. This study sought to identify more specific patterns of oral sexual activity, including self-inoculation, that are associated with oral HPV infections in young women. METHODS: A total of 1010 women attending a large university completed a computer-based questionnaire and provided oral specimens that were tested for any oral HPV using a Linear Array assay that detects any HPV as well as 37 HPV genotypes. Twenty-seven women provided additional samples up to 12 months after enrollment. Bivariable and multivariable analyses were conducted to identify oral sexual patterns and other risk factors associated with prevalent oral HPV. RESULTS: Nineteen women had prevalent oral HPV (1.9%), with 10 women (1%) having a type-specific infection. Oral HPV was significantly associated with lifetime coital sex partnership numbers (P = 0.03), lifetime and yearly oral sex partnership numbers (P < 0.01), and hand and/or sex toy transfer from genitals to mouth (P < 0.001). Oral HPV was also associated with greater use of alcohol, cigarettes, marijuana, and sharing of smoking devices, lipstick, or toothbrushes (P < 0.05 for each), with an apparent dose-response for alcohol use and smoking behavior, stratified by number of sexual partners. Of 7 women with prevalent HPV who provided follow-up samples, none had evidence of a persistent type-specific infection. CONCLUSIONS: These data provide additional evidence of transmission of oral HPV from oral sexual activity and also suggest possible transmission from self-inoculation or sharing of oral products.

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