Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

INSIGHT-preAD Study Group, the Alzheimer Precision Medicine Initiative (APMI)

Research output: Contribution to journalReview articleResearchpeer-review

6 Citations (Scopus)

Abstract

Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.

Original languageEnglish
Pages (from-to)1204-1215
Number of pages12
JournalAlzheimer's and Dementia
Volume14
Issue number9
DOIs
StatePublished - 1 Sep 2018

Fingerprint

Functional Neuroimaging
Sex Characteristics
Alzheimer Disease
Biomarkers
Gyrus Cinguli
Amyloid
Brain
Genotype
Parietal Lobe
Fluorine
Neuroimaging
Positron-Emission Tomography
Hippocampus
Tomography
Glucose

Keywords

  • APOE
  • Aging
  • Alzheimer's disease
  • Amyloid
  • Basal forebrain
  • Cognitively intact older individuals
  • Cortical thickness
  • FDG-PET
  • Hippocampus
  • Metabolism
  • Sex

Cite this

INSIGHT-preAD Study Group ; the Alzheimer Precision Medicine Initiative (APMI). / Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. In: Alzheimer's and Dementia. 2018 ; Vol. 14, No. 9. pp. 1204-1215.
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title = "Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints",
abstract = "Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.",
keywords = "APOE, Aging, Alzheimer's disease, Amyloid, Basal forebrain, Cognitively intact older individuals, Cortical thickness, FDG-PET, Hippocampus, Metabolism, Sex",
author = "{INSIGHT-preAD Study Group} and {the Alzheimer Precision Medicine Initiative (APMI)} and Enrica Cavedo and Chiesa, {Patrizia A.} and Marion Houot and Ferretti, {Maria Teresa} and Grothe, {Michel J.} and Teipel, {Stefan J.} and Simone Lista and Habert, {Marie Odile} and Potier, {Marie Claude} and Bruno Dubois and Harald Hampel and Hovagim Bakardjian and Habib Benali and Hugo Bertin and Joel Bonheur and Laurie Boukadida and Nadia Boukerrou and Enrica Cavedo and Patrizia Chiesa and Olivier Colliot and Bruno Dubois and Marion Dubois and St{\'e}phane Epelbaum and Geoffroy Gagliardi and Remy Genthon and Habert, {Marie Odile} and Harald Hampel and Marion Houot and Aur{\'e}lie Kas and Foudil Lamari and Marcel Levy and Simone Lista and Christiane Metzinger and Fanny Mochel and Francis Nyasse and Catherine Poisson and Potier, {Marie Claude} and Marie Revillon and Antonio Santos and Andrade, {Katia Santos} and Marine Sole and Mohmed Surtee and {de Schotten}, {Michel Thiebaud} and Andrea Vergallo and Nadjia Younsi and Aguilar, {Lisi Flores} and Claudio Babiloni and Filippo Baldacci and Norbert Benda and Sidney O'Bryant",
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Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. / INSIGHT-preAD Study Group; the Alzheimer Precision Medicine Initiative (APMI).

In: Alzheimer's and Dementia, Vol. 14, No. 9, 01.09.2018, p. 1204-1215.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

AU - INSIGHT-preAD Study Group

AU - the Alzheimer Precision Medicine Initiative (APMI)

AU - Cavedo, Enrica

AU - Chiesa, Patrizia A.

AU - Houot, Marion

AU - Ferretti, Maria Teresa

AU - Grothe, Michel J.

AU - Teipel, Stefan J.

AU - Lista, Simone

AU - Habert, Marie Odile

AU - Potier, Marie Claude

AU - Dubois, Bruno

AU - Hampel, Harald

AU - Bakardjian, Hovagim

AU - Benali, Habib

AU - Bertin, Hugo

AU - Bonheur, Joel

AU - Boukadida, Laurie

AU - Boukerrou, Nadia

AU - Cavedo, Enrica

AU - Chiesa, Patrizia

AU - Colliot, Olivier

AU - Dubois, Bruno

AU - Dubois, Marion

AU - Epelbaum, Stéphane

AU - Gagliardi, Geoffroy

AU - Genthon, Remy

AU - Habert, Marie Odile

AU - Hampel, Harald

AU - Houot, Marion

AU - Kas, Aurélie

AU - Lamari, Foudil

AU - Levy, Marcel

AU - Lista, Simone

AU - Metzinger, Christiane

AU - Mochel, Fanny

AU - Nyasse, Francis

AU - Poisson, Catherine

AU - Potier, Marie Claude

AU - Revillon, Marie

AU - Santos, Antonio

AU - Andrade, Katia Santos

AU - Sole, Marine

AU - Surtee, Mohmed

AU - de Schotten, Michel Thiebaud

AU - Vergallo, Andrea

AU - Younsi, Nadjia

AU - Aguilar, Lisi Flores

AU - Babiloni, Claudio

AU - Baldacci, Filippo

AU - Benda, Norbert

AU - O'Bryant, Sidney

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.

AB - Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.

KW - APOE

KW - Aging

KW - Alzheimer's disease

KW - Amyloid

KW - Basal forebrain

KW - Cognitively intact older individuals

KW - Cortical thickness

KW - FDG-PET

KW - Hippocampus

KW - Metabolism

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=85052864283&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2018.05.014

DO - 10.1016/j.jalz.2018.05.014

M3 - Review article

VL - 14

SP - 1204

EP - 1215

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 9

ER -