Abstract
Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1204-1215 |
| Number of pages | 12 |
| Journal | Alzheimer's and Dementia |
| Volume | 14 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2018 |
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Keywords
- APOE
- Aging
- Alzheimer's disease
- Amyloid
- Basal forebrain
- Cognitively intact older individuals
- Cortical thickness
- FDG-PET
- Hippocampus
- Metabolism
- Sex
Cite this
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Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. / INSIGHT-preAD Study Group; the Alzheimer Precision Medicine Initiative (APMI).
In: Alzheimer's and Dementia, Vol. 14, No. 9, 09.2018, p. 1204-1215.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints
AU - INSIGHT-preAD Study Group
AU - the Alzheimer Precision Medicine Initiative (APMI)
AU - Cavedo, Enrica
AU - Chiesa, Patrizia A.
AU - Houot, Marion
AU - Ferretti, Maria Teresa
AU - Grothe, Michel J.
AU - Teipel, Stefan J.
AU - Lista, Simone
AU - Habert, Marie Odile
AU - Potier, Marie Claude
AU - Dubois, Bruno
AU - Hampel, Harald
AU - Bakardjian, Hovagim
AU - Benali, Habib
AU - Bertin, Hugo
AU - Bonheur, Joel
AU - Boukadida, Laurie
AU - Boukerrou, Nadia
AU - Cavedo, Enrica
AU - Chiesa, Patrizia
AU - Colliot, Olivier
AU - Dubois, Bruno
AU - Dubois, Marion
AU - Epelbaum, Stéphane
AU - Gagliardi, Geoffroy
AU - Genthon, Remy
AU - Habert, Marie Odile
AU - Hampel, Harald
AU - Houot, Marion
AU - Kas, Aurélie
AU - Lamari, Foudil
AU - Levy, Marcel
AU - Lista, Simone
AU - Metzinger, Christiane
AU - Mochel, Fanny
AU - Nyasse, Francis
AU - Poisson, Catherine
AU - Potier, Marie Claude
AU - Revillon, Marie
AU - Santos, Antonio
AU - Andrade, Katia Santos
AU - Sole, Marine
AU - Surtee, Mohmed
AU - de Schotten, Michel Thiebaud
AU - Vergallo, Andrea
AU - Younsi, Nadjia
AU - Aguilar, Lisi Flores
AU - Babiloni, Claudio
AU - Baldacci, Filippo
AU - Benda, Norbert
AU - Black, Keith L.
PY - 2018/9
Y1 - 2018/9
N2 - Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.
AB - Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001) and inferior parietal (P =.043) cortices, and lower resting-state functional connectivity in the default mode network (P =.024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.
KW - APOE
KW - Aging
KW - Alzheimer's disease
KW - Amyloid
KW - Basal forebrain
KW - Cognitively intact older individuals
KW - Cortical thickness
KW - FDG-PET
KW - Hippocampus
KW - Metabolism
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=85052864283&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2018.05.014
DO - 10.1016/j.jalz.2018.05.014
M3 - Review article
C2 - 30201102
AN - SCOPUS:85052864283
VL - 14
SP - 1204
EP - 1215
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
IS - 9
ER -