Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke

X. L. Chen, Q. Li, W. S. Huang, Y. S. Lin, J. Xue, B. Wang, Kunlin Jin, B. Shao

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background and purpose: Inflammation comprises important aspects of large-artery atherosclerosis (LAA) stroke pathophysiology. YKL-40 is a new and emerging biomarker that is associated with both acute and chronic inflammations. Elevated serum concentrations of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases. This study investigates whether serum YKL-40 concentrations on admission can predict 3-month clinical outcomes after LAA stroke. Methods: We recruited control patients (n=85) and those with LAA stroke (n=141) according to the TOAST classification system. The modified Rankin scale at 3 months after stroke was used to evaluate the prognosis. The prognostic accuracy was assessed by the receiver operating characteristic curve. Results: Serum YKL-40 level was significantly higher for LAA patients than for controls (P<.001). Patients with poor outcomes (n=36) had significantly increased serum YKL-40 concentrations on admission (P=.01). High YKL-40 levels predicted poor functional outcome (OR=6.47, P=.02). Moreover, the combination of YKL-40 level and the NIHSS score could improve the prognostic accuracy of the NIHSS in predicting functional outcome (combined areas under the curve, 0.87; 95% CI, 0.80-0.94; P<.001). Conclusions: The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome of LAA stroke.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalActa Neurologica Scandinavica
Volume136
Issue number2
DOIs
StatePublished - 1 Aug 2017

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Atherosclerosis
Arteries
Stroke
Serum
Biomarkers
Inflammation
ROC Curve
Area Under Curve
Cardiovascular Diseases

Keywords

  • YKL-40
  • atherosclerosis
  • outcome
  • stroke

Cite this

Chen, X. L., Li, Q., Huang, W. S., Lin, Y. S., Xue, J., Wang, B., ... Shao, B. (2017). Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke. Acta Neurologica Scandinavica, 136(2), 97-102. https://doi.org/10.1111/ane.12688
Chen, X. L. ; Li, Q. ; Huang, W. S. ; Lin, Y. S. ; Xue, J. ; Wang, B. ; Jin, Kunlin ; Shao, B. / Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke. In: Acta Neurologica Scandinavica. 2017 ; Vol. 136, No. 2. pp. 97-102.
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abstract = "Background and purpose: Inflammation comprises important aspects of large-artery atherosclerosis (LAA) stroke pathophysiology. YKL-40 is a new and emerging biomarker that is associated with both acute and chronic inflammations. Elevated serum concentrations of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases. This study investigates whether serum YKL-40 concentrations on admission can predict 3-month clinical outcomes after LAA stroke. Methods: We recruited control patients (n=85) and those with LAA stroke (n=141) according to the TOAST classification system. The modified Rankin scale at 3 months after stroke was used to evaluate the prognosis. The prognostic accuracy was assessed by the receiver operating characteristic curve. Results: Serum YKL-40 level was significantly higher for LAA patients than for controls (P<.001). Patients with poor outcomes (n=36) had significantly increased serum YKL-40 concentrations on admission (P=.01). High YKL-40 levels predicted poor functional outcome (OR=6.47, P=.02). Moreover, the combination of YKL-40 level and the NIHSS score could improve the prognostic accuracy of the NIHSS in predicting functional outcome (combined areas under the curve, 0.87; 95{\%} CI, 0.80-0.94; P<.001). Conclusions: The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome of LAA stroke.",
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Chen, XL, Li, Q, Huang, WS, Lin, YS, Xue, J, Wang, B, Jin, K & Shao, B 2017, 'Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke', Acta Neurologica Scandinavica, vol. 136, no. 2, pp. 97-102. https://doi.org/10.1111/ane.12688

Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke. / Chen, X. L.; Li, Q.; Huang, W. S.; Lin, Y. S.; Xue, J.; Wang, B.; Jin, Kunlin; Shao, B.

In: Acta Neurologica Scandinavica, Vol. 136, No. 2, 01.08.2017, p. 97-102.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke

AU - Chen, X. L.

AU - Li, Q.

AU - Huang, W. S.

AU - Lin, Y. S.

AU - Xue, J.

AU - Wang, B.

AU - Jin, Kunlin

AU - Shao, B.

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N2 - Background and purpose: Inflammation comprises important aspects of large-artery atherosclerosis (LAA) stroke pathophysiology. YKL-40 is a new and emerging biomarker that is associated with both acute and chronic inflammations. Elevated serum concentrations of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases. This study investigates whether serum YKL-40 concentrations on admission can predict 3-month clinical outcomes after LAA stroke. Methods: We recruited control patients (n=85) and those with LAA stroke (n=141) according to the TOAST classification system. The modified Rankin scale at 3 months after stroke was used to evaluate the prognosis. The prognostic accuracy was assessed by the receiver operating characteristic curve. Results: Serum YKL-40 level was significantly higher for LAA patients than for controls (P<.001). Patients with poor outcomes (n=36) had significantly increased serum YKL-40 concentrations on admission (P=.01). High YKL-40 levels predicted poor functional outcome (OR=6.47, P=.02). Moreover, the combination of YKL-40 level and the NIHSS score could improve the prognostic accuracy of the NIHSS in predicting functional outcome (combined areas under the curve, 0.87; 95% CI, 0.80-0.94; P<.001). Conclusions: The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome of LAA stroke.

AB - Background and purpose: Inflammation comprises important aspects of large-artery atherosclerosis (LAA) stroke pathophysiology. YKL-40 is a new and emerging biomarker that is associated with both acute and chronic inflammations. Elevated serum concentrations of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases. This study investigates whether serum YKL-40 concentrations on admission can predict 3-month clinical outcomes after LAA stroke. Methods: We recruited control patients (n=85) and those with LAA stroke (n=141) according to the TOAST classification system. The modified Rankin scale at 3 months after stroke was used to evaluate the prognosis. The prognostic accuracy was assessed by the receiver operating characteristic curve. Results: Serum YKL-40 level was significantly higher for LAA patients than for controls (P<.001). Patients with poor outcomes (n=36) had significantly increased serum YKL-40 concentrations on admission (P=.01). High YKL-40 levels predicted poor functional outcome (OR=6.47, P=.02). Moreover, the combination of YKL-40 level and the NIHSS score could improve the prognostic accuracy of the NIHSS in predicting functional outcome (combined areas under the curve, 0.87; 95% CI, 0.80-0.94; P<.001). Conclusions: The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome of LAA stroke.

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