Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics

Panama Aging Research Initiative

doi:10.2217/nmt-2015-0009

Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics

Panama Aging Research Initiative

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

AIM: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.

METHODS: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.

RESULTS: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.

CONCLUSION: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.

Original language	English
Pages (from-to)	203-213
Number of pages	11
Journal	Neurodegenerative disease management
Volume	6
Issue number	3
DOIs	https://doi.org/10.2217/nmt-2015-0009
State	Published - 1 Jun 2016

Keywords

Hispanic
Latin America
aging
blood-based biomarkers
cognition
dementia

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10.2217/nmt-2015-0009

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abstract = "AIM: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.METHODS: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.RESULTS: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.CONCLUSION: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.",

keywords = "Hispanic, Latin America, aging, blood-based biomarkers, cognition, dementia",

author = "{Panama Aging Research Initiative} and Villarreal, {Alcibiades E.} and O'Bryant, {Sid E.} and Melissa Edwards and Shantal Grajales and Britton, {Gabrielle B.}",

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doi = "10.2217/nmt-2015-0009",

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T1 - Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics

AU - Panama Aging Research Initiative

AU - Villarreal, Alcibiades E.

AU - O'Bryant, Sid E.

AU - Edwards, Melissa

AU - Grajales, Shantal

AU - Britton, Gabrielle B.

PY - 2016/6/1

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N2 - AIM: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.METHODS: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.RESULTS: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.CONCLUSION: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.

AB - AIM: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.METHODS: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.RESULTS: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.CONCLUSION: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.

KW - Hispanic

KW - Latin America

KW - aging

KW - blood-based biomarkers

KW - cognition

KW - dementia

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Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics

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Keywords

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