Abstract
AIM: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.
METHODS: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.
RESULTS: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.
CONCLUSION: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.
Original language | English |
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Pages (from-to) | 203-213 |
Number of pages | 11 |
Journal | Neurodegenerative disease management |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - 1 Jun 2016 |
Keywords
- Hispanic
- Latin America
- aging
- blood-based biomarkers
- cognition
- dementia