Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics

Panama Aging Research Initiative

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

AIM: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.

METHODS: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.

RESULTS: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.

CONCLUSION: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalNeurodegenerative disease management
Volume6
Issue number3
DOIs
StatePublished - 1 Jun 2016

Keywords

  • Hispanic
  • Latin America
  • aging
  • blood-based biomarkers
  • cognition
  • dementia

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