TY - JOUR
T1 - Sequence polymorphism of the mitochondrial DNA hypervariable regions I and II in 205 Singapore Malays
AU - Wong, Hang Yee
AU - Tang, June S.W.
AU - Budowle, Bruce
AU - Allard, Marc W.
AU - Syn, Christopher K.C.
AU - Tan-Siew, Wai Fun
AU - Chow, Shui Tse
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Mitochondrial DNA sequences of the hypervariable regions HV1 and HV2 were analyzed in 205 unrelated ethnic Malays residing in Singapore as an initial effort to generate a database for forensic identification purposes. Sequence polymorphism was detected using PCR and direct sequencing analysis. A total of 152 haplotypes was found containing 152 polymorphisms. Out of the 152 haplotypes, 115 were observed only once and 37 types were seen in multiple individuals. The most common haplotype (16223T, 16295T, 16362C, 73G, 146C, 199C, 263G, and 315.1C) was shared by 7 (3.41%) individuals, two haplotypes were shared by 4 individuals, seven haplotypes were shared by 3 individuals, and 27 haplotypes by 2 individuals. Haplotype diversity and random match probability were estimated to be 0.9961% and 0.87%, respectively. Crown
AB - Mitochondrial DNA sequences of the hypervariable regions HV1 and HV2 were analyzed in 205 unrelated ethnic Malays residing in Singapore as an initial effort to generate a database for forensic identification purposes. Sequence polymorphism was detected using PCR and direct sequencing analysis. A total of 152 haplotypes was found containing 152 polymorphisms. Out of the 152 haplotypes, 115 were observed only once and 37 types were seen in multiple individuals. The most common haplotype (16223T, 16295T, 16362C, 73G, 146C, 199C, 263G, and 315.1C) was shared by 7 (3.41%) individuals, two haplotypes were shared by 4 individuals, seven haplotypes were shared by 3 individuals, and 27 haplotypes by 2 individuals. Haplotype diversity and random match probability were estimated to be 0.9961% and 0.87%, respectively. Crown
KW - Haplogroups
KW - Haplotypes
KW - Heteroplasmy
KW - Sequence polymorphism
KW - Singapore Malay population
KW - mtDNA
UR - http://www.scopus.com/inward/record.url?scp=33845380743&partnerID=8YFLogxK
U2 - 10.1016/j.legalmed.2006.08.007
DO - 10.1016/j.legalmed.2006.08.007
M3 - Article
C2 - 17150401
AN - SCOPUS:33845380743
VL - 9
SP - 33
EP - 37
JO - Legal Medicine
JF - Legal Medicine
SN - 1344-6223
IS - 1
ER -