Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death

Yogesh C. Awasthi, Rajendra Sharma, Abha Sharma, Sushma Yadav, Sharad S. Singhal, Pankaj Chaudhary, Sanjay Awasthi

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Within the last two decades, 4-hydroxynonenal has emerged as an important second messenger involved in the regulation of various cellular processes. Our recent studies suggest that HNE can induce apoptosis in various cells through the death receptor Fas (CD95)-mediated extrinsic pathway as well as through the p53-dependent intrinsic pathway. Interestingly, through its interaction with the nuclear protein Daxx, HNE can self-limit its apoptotic role by translocating Daxx to cytoplasm where it binds to Fas and inhibits Fas-mediated apoptosis. In this paper, after briefly describing recent studies on various biological activities of HNE, based on its interactions with Fas, Daxx, and p53, we speculate on possible mechanisms through which HNE may affect a multitude of cellular processes and draw a parallel between signaling roles of H2O2 and HNE.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalFree Radical Biology and Medicine
Issue number2
StatePublished - 15 Jul 2008


  • 4-Hydroxynonenal
  • Apoptosis
  • Cell cycle signalling
  • Daxx
  • Fas
  • Heat shock factor 1
  • P53


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