Secondary Conformational Checkpoint in CRISPR-Cas9

Keyphrases

• Cas9 Protein 100%
• DNA Cleavage 100%
• Gene Editing 66%
• Basis Mismatch 66%
• Activation Mechanism 33%
• Conformational Transition 33%
• HNH Endonuclease 33%
• Cas9 Variants 33%
• HNH Domain 33%
• Target DNA 33%
• DNA Binding 33%
• Conformational Activation 33%
• Guide RNA (gRNA) 33%
• Allosteric Communication 33%
• Cleavage Activation 33%
• Motion Mode 33%
• Dynamic Simulation 33%
• MRNA Variants 33%
• Sub-millisecond 33%
• Functional Mode 33%

Immunology and Microbiology

• CRISPR/Cas9 100%
• DNA Cleavage 100%
• Gene Editing 66%
• Motion 33%
• DNA Binding 33%
• Conformational Transition 33%
• Nuclease 33%
• Ribonucleic Acid 33%

Biochemistry, Genetics and Molecular Biology

• Cas9 100%
• CRISPR/Cas9 100%
• DNA Cleavage 42%
• Genome Editing 28%
• Enzyme 14%
• Conformational Change 14%
• Motion 14%
• DNA Binding 14%
• Guide RNA 14%
• Nuclease 14%