TY - JOUR
T1 - Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion
AU - Panchoo, Marlyn
AU - Lacko, Andras
N1 - Funding Information:
The research of the investigators involved was supported in part by CPRIT ( DP150091 ); Wheels for Wellness, Fort Worth, TX, USA ; and the Rutledge Foundation .
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Neuroblastoma (NB) is an extra cranial pediatric embryonal tumor most prevalent in children less than 1 year of age. NB accounts for 7% of all pediatric cancers but accounts for 15% of all childhood cancer deaths. Scavenger receptor class B type 1 (SR-B1), a mediator of cellular cholesterol uptake, is overexpressed in and have been linked to the aggressiveness of many cancers. Nevertheless, no studies have so far investigated the relationship between SR-B1 and NB. Elucidation of receptors that promote NB may pave the way for discovery of new therapeutic targets. Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.
AB - Neuroblastoma (NB) is an extra cranial pediatric embryonal tumor most prevalent in children less than 1 year of age. NB accounts for 7% of all pediatric cancers but accounts for 15% of all childhood cancer deaths. Scavenger receptor class B type 1 (SR-B1), a mediator of cellular cholesterol uptake, is overexpressed in and have been linked to the aggressiveness of many cancers. Nevertheless, no studies have so far investigated the relationship between SR-B1 and NB. Elucidation of receptors that promote NB may pave the way for discovery of new therapeutic targets. Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.
KW - Cholesterol metabolism
KW - Neuroblastoma
KW - Scavenger receptor class B type 1
UR - http://www.scopus.com/inward/record.url?scp=85035100973&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2017.10.154
DO - 10.1016/j.bbrc.2017.10.154
M3 - Article
C2 - 29128352
AN - SCOPUS:85035100973
SN - 0006-291X
VL - 495
SP - 614
EP - 620
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -