Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion

Marlyn Panchoo, Andras Lacko

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Neuroblastoma (NB) is an extra cranial pediatric embryonal tumor most prevalent in children less than 1 year of age. NB accounts for 7% of all pediatric cancers but accounts for 15% of all childhood cancer deaths. Scavenger receptor class B type 1 (SR-B1), a mediator of cellular cholesterol uptake, is overexpressed in and have been linked to the aggressiveness of many cancers. Nevertheless, no studies have so far investigated the relationship between SR-B1 and NB. Elucidation of receptors that promote NB may pave the way for discovery of new therapeutic targets. Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.

Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume495
Issue number1
DOIs
StatePublished - 1 Jan 2018

Keywords

  • Cholesterol metabolism
  • Neuroblastoma
  • Scavenger receptor class B type 1

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