Safety and tolerability of high-dose weekly liposomal amphotericin B antifungal prophylaxis

Elizabeth O. Hand; Meenakshi R. Ramanathan

doi:10.1097/INF.0000000000000335

Safety and tolerability of high-dose weekly liposomal amphotericin B antifungal prophylaxis

Elizabeth O. Hand, Meenakshi R. Ramanathan

Pharmacotherapy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Children with hematologic malignancies are at an increased risk of invasive fungal infections and a greater risk has been seen with exposure to building construction. Prophylaxis with high-dose (IV) liposomal amphotericin B (L-AmB) 10 mg/kg once weekly was initiated in our high risk children based on previous pharmacokinetic studies. This treatment regimen was associated with a 26% incidence of adverse infusion reactions.

Original language	English
Pages (from-to)	835-836
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	8
DOIs	https://doi.org/10.1097/INF.0000000000000335
State	Published - Aug 2014

Keywords

Amphotericin B
Prophylaxis
Tolerability

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10.1097/INF.0000000000000335

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abstract = "Children with hematologic malignancies are at an increased risk of invasive fungal infections and a greater risk has been seen with exposure to building construction. Prophylaxis with high-dose (IV) liposomal amphotericin B (L-AmB) 10 mg/kg once weekly was initiated in our high risk children based on previous pharmacokinetic studies. This treatment regimen was associated with a 26% incidence of adverse infusion reactions.",

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KW - Tolerability

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Safety and tolerability of high-dose weekly liposomal amphotericin B antifungal prophylaxis

Abstract

Keywords

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