Safety and tolerability of high-dose weekly liposomal amphotericin B antifungal prophylaxis

Elizabeth O. Hand, Meenakshi R. Ramanathan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Children with hematologic malignancies are at an increased risk of invasive fungal infections and a greater risk has been seen with exposure to building construction. Prophylaxis with high-dose (IV) liposomal amphotericin B (L-AmB) 10 mg/kg once weekly was initiated in our high risk children based on previous pharmacokinetic studies. This treatment regimen was associated with a 26% incidence of adverse infusion reactions.

Original languageEnglish
Pages (from-to)835-836
Number of pages2
JournalPediatric Infectious Disease Journal
Volume33
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Amphotericin B
  • Prophylaxis
  • Tolerability

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