Role of virally‐encoded deubiquitinating enzymes in regulation of the virus life cycle

Jessica Proulx, Kathleen Borgmann, In Woo Park

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numer-ous cellular processes, including innate and adaptive immune responses that are essential for re-striction of the virus life cycle in the infected cells. Deubiquitination by the deubiquitinating en-zyme, deubiquitinase (DUB), is a reversible molecular process to remove Ub or Ub chains from the target proteins. Deubiquitination is an integral strategy within the UPS in regulating survival and proliferation of the infecting virus and the virus‐invaded cells. Many viruses in the infected cells are reported to encode viral DUB, and these vial DUBs actively disrupt cellular Ub‐dependent processes to suppress host antiviral immune response, enhancing virus replication and thus proliferation. This review surveys the types of DUBs encoded by different viruses and their molecular processes for how the infecting viruses take advantage of the DUB system to evade the host immune response and expedite their replication.

Original languageEnglish
Article number4438
JournalInternational journal of molecular sciences
Issue number9
StatePublished - 1 May 2021


  • Deubiquitinases (DUBs)
  • Ubiquitin proteasome system
  • Ubiquitination
  • Viruses


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