Role of the endothelium in inflammatory bowel diseases

Walter E. Cromer, James Michael Mathis, Daniel N. Granger, Ganta V. Chaitanya, J. Steven Alexander

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Inflammatory bowel diseases (IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease. At the core of these alterations are endothelial cells, whose continual adjustments in structure and function coordinate vascular supply, immune cell emigration, and regulation of the tissue environment. Expansion of the endothelium in IBD (angiogenesis), mediated by inflammatory growth factors, cytokines and chemokines, is a hallmark of active gut disease and is closely related to disease severity. The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines, growth factors, and adhesion molecules, altering coagulant capacity, barrier function and blood cell recruitment in injury. This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions.

Original languageEnglish
Pages (from-to)578-593
Number of pages16
JournalWorld Journal of Gastroenterology
Volume17
Issue number5
DOIs
StatePublished - 7 Feb 2011

Fingerprint

Inflammatory Bowel Diseases
Endothelium
Intercellular Signaling Peptides and Proteins
Cytokines
Mucosal Immunity
Coagulants
Emigration and Immigration
Chemokines
Blood Vessels
Blood Cells
Endothelial Cells
Pathology
Wounds and Injuries

Keywords

  • Adhesion molecules
  • Chemokines
  • Crohn's disease
  • Cytokines
  • Endothelium
  • Growth factors
  • Inflammation
  • Microvasculature
  • Nitric oxide
  • Ulcerative colitis

Cite this

Cromer, W. E., Mathis, J. M., Granger, D. N., Chaitanya, G. V., & Alexander, J. S. (2011). Role of the endothelium in inflammatory bowel diseases. World Journal of Gastroenterology, 17(5), 578-593. https://doi.org/10.3748/wjg.v17.i5.578
Cromer, Walter E. ; Mathis, James Michael ; Granger, Daniel N. ; Chaitanya, Ganta V. ; Alexander, J. Steven. / Role of the endothelium in inflammatory bowel diseases. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 5. pp. 578-593.
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Cromer, WE, Mathis, JM, Granger, DN, Chaitanya, GV & Alexander, JS 2011, 'Role of the endothelium in inflammatory bowel diseases', World Journal of Gastroenterology, vol. 17, no. 5, pp. 578-593. https://doi.org/10.3748/wjg.v17.i5.578

Role of the endothelium in inflammatory bowel diseases. / Cromer, Walter E.; Mathis, James Michael; Granger, Daniel N.; Chaitanya, Ganta V.; Alexander, J. Steven.

In: World Journal of Gastroenterology, Vol. 17, No. 5, 07.02.2011, p. 578-593.

Research output: Contribution to journalArticle

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