Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ2-melanocyte-stimulating hormone (γ2-MSH)

Michael F. Callahan; J. Thomas Cunningham; Robert F. Kirby; Alan Kim Johnson; Kenneth A. Gruber

doi:10.1016/0006-8993(88)90925-0

Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ₂-melanocyte-stimulating hormone (γ₂-MSH)

Michael F. Callahan, J. Thomas Cunningham, Robert F. Kirby, Alan Kim Johnson, Kenneth A. Gruber

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We have examined the role of the anteroventral third ventricle (AV3V) region of the forebrain on the pressor responses to intravenous injections of the pituitary pressor agent, γ₂-melanocyte-stimulating hormone (γ₂-MSH) and the direct acting α₁-adrenergic agonist, phenylephrine in unanesthetized rats. Lesions of the AV3V region produce a parallel shift to the right in the dose response curve to γ₂-MSH, with no effect on the pressor response to phenylephrine. The lesion had no effect on the heart rate response to either agent. These experiments indicate that the forebrain region surrounding the anterior third ventricle area is important to some of the cardiovascular actions of γ₂-MSH.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Brain Research
Volume	444
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90925-0
State	Published - 15 Mar 1988

Keywords

Anteroventral third ventricle
Blood pressure
Heart rate
Sympathetic nervous system
γ-Melanocyte-stimulating hormone

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10.1016/0006-8993(88)90925-0

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title = "Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ2-melanocyte-stimulating hormone (γ2-MSH)",

abstract = "We have examined the role of the anteroventral third ventricle (AV3V) region of the forebrain on the pressor responses to intravenous injections of the pituitary pressor agent, γ2-melanocyte-stimulating hormone (γ2-MSH) and the direct acting α1-adrenergic agonist, phenylephrine in unanesthetized rats. Lesions of the AV3V region produce a parallel shift to the right in the dose response curve to γ2-MSH, with no effect on the pressor response to phenylephrine. The lesion had no effect on the heart rate response to either agent. These experiments indicate that the forebrain region surrounding the anterior third ventricle area is important to some of the cardiovascular actions of γ2-MSH.",

keywords = "Anteroventral third ventricle, Blood pressure, Heart rate, Sympathetic nervous system, γ-Melanocyte-stimulating hormone",

author = "Callahan, {Michael F.} and Cunningham, {J. Thomas} and Kirby, {Robert F.} and Johnson, {Alan Kim} and Gruber, {Kenneth A.}",

note = "Funding Information: Supported by the American Heart Association Iowa Affiliate Grant 85-4-9.",

year = "1988",

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doi = "10.1016/0006-8993(88)90925-0",

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AU - Callahan, Michael F.

AU - Cunningham, J. Thomas

AU - Kirby, Robert F.

AU - Johnson, Alan Kim

AU - Gruber, Kenneth A.

N1 - Funding Information: Supported by the American Heart Association Iowa Affiliate Grant 85-4-9.

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AB - We have examined the role of the anteroventral third ventricle (AV3V) region of the forebrain on the pressor responses to intravenous injections of the pituitary pressor agent, γ2-melanocyte-stimulating hormone (γ2-MSH) and the direct acting α1-adrenergic agonist, phenylephrine in unanesthetized rats. Lesions of the AV3V region produce a parallel shift to the right in the dose response curve to γ2-MSH, with no effect on the pressor response to phenylephrine. The lesion had no effect on the heart rate response to either agent. These experiments indicate that the forebrain region surrounding the anterior third ventricle area is important to some of the cardiovascular actions of γ2-MSH.

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KW - Blood pressure

KW - Heart rate

KW - Sympathetic nervous system

KW - γ-Melanocyte-stimulating hormone

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Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ₂-melanocyte-stimulating hormone (γ₂-MSH)

Abstract

Keywords

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