Role of sodium on H+ excretion in the integument of the leopard frog Rana pipiens

Ray Page, Loy W. Frazier, Thomas Yorio

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. 1. The northern leopard frog, Rana pipiens, pipiens, in contrast to the southern leopard frog, Rana pipiens, berlandieri, did not demonstrate any significant H+ excretion across its integument even during a challenge of chronic metabolic acidosis. Likewise, no increase in the number of H+ secreting mitochondria-rich cells were observed in the northern frogs. 2. 2. Under normal acid-base conditions in the southern frogs, H+ excretion was found to be dependent on mucosal sodium concentrations, whereas during chronic metabolic acidosis, H+ excretion was independent of mucosal sodium concentrations, but was amiloride sensitive. 3. 3. High salinity adapted southern frogs, under normal and acidotic conditions, had enhanced H4+ excretion rates as compared to the control non-salt adapted frogs. 4. 4. Blood analyses demonstrated that significant acid-base changes were the result of systemic acidosis and not due to salt adaptations. Blood Na+ and K+ concentrations were also efficiently maintained during salt adaptations or chronic metabolic acidosis. 5. 5. The results suggest that H+ excretion in epithelia can be influenced by the sodium transport state of the cell and the systemic acid-base profile. Models are proposed explaining these relationships.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume91
Issue number1
DOIs
StatePublished - 1 Jan 1988

Fingerprint

Rana pipiens
Acidosis
Anura
Sodium
Acids
Salts
Amiloride
Salinity
Mitochondria
Epithelium

Cite this

@article{7e26fbfd0991415b80afb7a13be0d8c2,
title = "Role of sodium on H+ excretion in the integument of the leopard frog Rana pipiens",
abstract = "1. 1. The northern leopard frog, Rana pipiens, pipiens, in contrast to the southern leopard frog, Rana pipiens, berlandieri, did not demonstrate any significant H+ excretion across its integument even during a challenge of chronic metabolic acidosis. Likewise, no increase in the number of H+ secreting mitochondria-rich cells were observed in the northern frogs. 2. 2. Under normal acid-base conditions in the southern frogs, H+ excretion was found to be dependent on mucosal sodium concentrations, whereas during chronic metabolic acidosis, H+ excretion was independent of mucosal sodium concentrations, but was amiloride sensitive. 3. 3. High salinity adapted southern frogs, under normal and acidotic conditions, had enhanced H4+ excretion rates as compared to the control non-salt adapted frogs. 4. 4. Blood analyses demonstrated that significant acid-base changes were the result of systemic acidosis and not due to salt adaptations. Blood Na+ and K+ concentrations were also efficiently maintained during salt adaptations or chronic metabolic acidosis. 5. 5. The results suggest that H+ excretion in epithelia can be influenced by the sodium transport state of the cell and the systemic acid-base profile. Models are proposed explaining these relationships.",
author = "Ray Page and Frazier, {Loy W.} and Thomas Yorio",
year = "1988",
month = "1",
day = "1",
doi = "10.1016/0300-9629(88)91591-5",
language = "English",
volume = "91",
pages = "53--59",
journal = "Comparative Biochemistry and Physiology -- Part A: Physiology",
issn = "0300-9629",
publisher = "Elsevier BV",
number = "1",

}

Role of sodium on H+ excretion in the integument of the leopard frog Rana pipiens. / Page, Ray; Frazier, Loy W.; Yorio, Thomas.

In: Comparative Biochemistry and Physiology -- Part A: Physiology, Vol. 91, No. 1, 01.01.1988, p. 53-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of sodium on H+ excretion in the integument of the leopard frog Rana pipiens

AU - Page, Ray

AU - Frazier, Loy W.

AU - Yorio, Thomas

PY - 1988/1/1

Y1 - 1988/1/1

N2 - 1. 1. The northern leopard frog, Rana pipiens, pipiens, in contrast to the southern leopard frog, Rana pipiens, berlandieri, did not demonstrate any significant H+ excretion across its integument even during a challenge of chronic metabolic acidosis. Likewise, no increase in the number of H+ secreting mitochondria-rich cells were observed in the northern frogs. 2. 2. Under normal acid-base conditions in the southern frogs, H+ excretion was found to be dependent on mucosal sodium concentrations, whereas during chronic metabolic acidosis, H+ excretion was independent of mucosal sodium concentrations, but was amiloride sensitive. 3. 3. High salinity adapted southern frogs, under normal and acidotic conditions, had enhanced H4+ excretion rates as compared to the control non-salt adapted frogs. 4. 4. Blood analyses demonstrated that significant acid-base changes were the result of systemic acidosis and not due to salt adaptations. Blood Na+ and K+ concentrations were also efficiently maintained during salt adaptations or chronic metabolic acidosis. 5. 5. The results suggest that H+ excretion in epithelia can be influenced by the sodium transport state of the cell and the systemic acid-base profile. Models are proposed explaining these relationships.

AB - 1. 1. The northern leopard frog, Rana pipiens, pipiens, in contrast to the southern leopard frog, Rana pipiens, berlandieri, did not demonstrate any significant H+ excretion across its integument even during a challenge of chronic metabolic acidosis. Likewise, no increase in the number of H+ secreting mitochondria-rich cells were observed in the northern frogs. 2. 2. Under normal acid-base conditions in the southern frogs, H+ excretion was found to be dependent on mucosal sodium concentrations, whereas during chronic metabolic acidosis, H+ excretion was independent of mucosal sodium concentrations, but was amiloride sensitive. 3. 3. High salinity adapted southern frogs, under normal and acidotic conditions, had enhanced H4+ excretion rates as compared to the control non-salt adapted frogs. 4. 4. Blood analyses demonstrated that significant acid-base changes were the result of systemic acidosis and not due to salt adaptations. Blood Na+ and K+ concentrations were also efficiently maintained during salt adaptations or chronic metabolic acidosis. 5. 5. The results suggest that H+ excretion in epithelia can be influenced by the sodium transport state of the cell and the systemic acid-base profile. Models are proposed explaining these relationships.

UR - http://www.scopus.com/inward/record.url?scp=0023677090&partnerID=8YFLogxK

U2 - 10.1016/0300-9629(88)91591-5

DO - 10.1016/0300-9629(88)91591-5

M3 - Article

C2 - 2904333

AN - SCOPUS:0023677090

VL - 91

SP - 53

EP - 59

JO - Comparative Biochemistry and Physiology -- Part A: Physiology

JF - Comparative Biochemistry and Physiology -- Part A: Physiology

SN - 0300-9629

IS - 1

ER -