Role of sodium on H+ excretion in the integument of the leopard frog Rana pipiens

Ray Page, Loy W. Frazier, Thomas Yorio

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Abstract

1. 1. The northern leopard frog, Rana pipiens, pipiens, in contrast to the southern leopard frog, Rana pipiens, berlandieri, did not demonstrate any significant H+ excretion across its integument even during a challenge of chronic metabolic acidosis. Likewise, no increase in the number of H+ secreting mitochondria-rich cells were observed in the northern frogs. 2. 2. Under normal acid-base conditions in the southern frogs, H+ excretion was found to be dependent on mucosal sodium concentrations, whereas during chronic metabolic acidosis, H+ excretion was independent of mucosal sodium concentrations, but was amiloride sensitive. 3. 3. High salinity adapted southern frogs, under normal and acidotic conditions, had enhanced H4+ excretion rates as compared to the control non-salt adapted frogs. 4. 4. Blood analyses demonstrated that significant acid-base changes were the result of systemic acidosis and not due to salt adaptations. Blood Na+ and K+ concentrations were also efficiently maintained during salt adaptations or chronic metabolic acidosis. 5. 5. The results suggest that H+ excretion in epithelia can be influenced by the sodium transport state of the cell and the systemic acid-base profile. Models are proposed explaining these relationships.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume91
Issue number1
DOIs
Publication statusPublished - 1988

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